A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat
- 74 Downloads
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides. It was shown that the oximes were potent antidotes in poisoning with phosphate insecticides. Obidoxime, pradidoxime and HI-6 had low effectiveness in the treatment of poisoning with phosphonates and phosphorothiolates. However, none of the oximes was an effective antidote in poisoning with dimethoate and pyridafenthion. Trimedoxime was the most effective oxime in the treatment of insecticide poisoning, being successful especially at the lowest tested doses.
Key wordsTreatment of poisoning Antidotes Organophosphorus insecticides Oximes Toxicity Trimedoxime Obidoxime Pralidoxime HI-6
Unable to display preview. Download preview PDF.
- Binenfeld Z (1986) Medical protection against nerve gas poisoning Past, present and future trend. A critical appraisal. Proceedings of 2nd International Symposium “Protection against Chemical Warfare Agents”, Stockholm, pp 315–321Google Scholar
- Jovanović D, Bošković B (1983) Current problems in the experimental treatment of dimethoate poisoning by cholinesterase reactivators. Acta Vet (Beograd) 33: 21–28Google Scholar
- Kušić R, Randjelović S, Jovanović D, Joksović D, Todorović V, Bošković B, Vojvodić V (1989) Clinical experience with application of a new oxime (HI-6) in poisoning by organophosphorus compounds. Proceedings of the 3rd International Symposium “Protection against Chemical Warfare Agents”, Umea, pp 141–149Google Scholar
- Maksimović M, Bošković B, Radović Lj, Tadić V, Deljac V, Binenfeld Z (1980) Antidotal, effects of bis-pyridinium-2-monoxime carbonyl derivatives in intoxications with highly toxic organophosphorus compounds. Acta Pharm Jugosl 30: 151–160Google Scholar
- Milošević M, Vojvodić V, Terzić M (1967) Blood concentrations ofN, N′-trimethylenebis(pyridinium-4-aldoxime) (TMB-4) andN-N′-oxydimethylenebis(pyridinium-4-aldoxime) (toxogonin) after intravenous and intramuscular administration in the dog. Biochem Pharmacol 16: 2435–2438PubMedCrossRefGoogle Scholar
- Sanderson DM, Edson EF (1964) Toxicological properties of the organophosphorus insecticide dimethoate. Br J Industr Med 21: 52–64Google Scholar
- Sterling GH (1983) Poisoning by cholinesterase-inhibiting insecticides. Am Family Phys 27: 159–162Google Scholar
- World Health Organization (1986) Organophosphorus insecticides: a general introduction. Environmental Health Criteria 63, GenevaGoogle Scholar
- Zech R, Engelhard H, Erdmann WD (1967) Phosphorylation of cholinesterases by various organophosphates in the presence and absence of oximes. Proceedings of the Conference on structure and reactions of DFP sensitive enzymes, Stockholm, pp 179–186Google Scholar