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Effect of antithyroid autoantibodies on pancreatic islet-cell function

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Summary

Insulin-dependent diabetes mellitus is frequently associated with organ-specific autoimmune diseases and/or high titers of organ-specific autoantibodies. The effects of thyroid autoantibodies on islet-cell function were examined in the present study. Islet cell surface antibody (ICSAb) was detected in sera from 6 of 40 patients with autoimmune thyroid disease (AITD) who were positive for thyroid microsomal autoantibodies (TMA). Furthermore, all of the ICSAb-positive patients had high TMA titers.In vitro study using isolated rat pancreatic islets revealed that TMA positive sera significantly suppressed glucose-induced insulin release. Only one of 19 (5%) AITD patients showed complement-dependent antibody-mediated cytotoxicity and only one of 6 AITD patients (17%) was positive for antibody-dependent cellular cytotoxicity. These results suggest that TMA has an effect on an antigen of the islet cell membrane in which insulin releasing mechanism might be involved.

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Authors and Affiliations

  1. Second Division, Department of Internal Medicine, Kyoto University School of Medicine, 54 Kawara-cho, Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Norikazu Kitano, Michiyo Seno & Hiroo Imura

  2. Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Kyoto

    Tomohiko Taminato & Yutaka Seino

  3. Hyogo Prefectural Amagasaki Hospital, Amagasaki

    Yoshikatsu Miyamoto

  4. Third Division, Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan

    Shigeru Matsukura

Authors
  1. Norikazu Kitano
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  2. Tomohiko Taminato
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  3. Michiyo Seno
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  4. Yoshikatsu Miyamoto
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  5. Yutaka Seino
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  6. Shigeru Matsukura
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  7. Hiroo Imura
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Kitano, N., Taminato, T., Seno, M. et al. Effect of antithyroid autoantibodies on pancreatic islet-cell function. Acta diabet. lat 24, 9–15 (1987). https://doi.org/10.1007/BF02732048

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  • DOI: https://doi.org/10.1007/BF02732048

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