Skip to main content

Childhood autism in tuberous sclerosis

Abstract

The article reports two cases of childhood autism in tuberous sclerosis (TS). Certain atypical features are highlighted. The probands did not show the common seizure types associated with either TS or autism. No ventricular dilatation, cerebral atrophy or temporal lobe involvement was evident. The high prevalence of childhood autism in TS probands with moderate to severe mental retardation has been emphasized.

This is a preview of subscription content, access via your institution.

References

  1. Gillberg C. The neurobiology of infantile autism.J Child Psychol Psychiatry 1988; 29:257–266.

    PubMed  Article  CAS  Google Scholar 

  2. Smalley SL, Tanguary PE, Smith M, Gutierrez G. Autism and tuberous sclerosis.J Autism Dev Disord 1992; 22: 339–355.

    PubMed  Article  CAS  Google Scholar 

  3. Hunt A, Shepherd C. A prevalence study of autism in tuberous scleroses.J Autism Dev Disord 1993; 23: 323–339.

    PubMed  Article  CAS  Google Scholar 

  4. World Health Organization.The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diganostic Guidelines. Geneva : WHO, 1992.

    Google Scholar 

  5. Khanna R, Sood M. Autism in tuberous scleroses.Indian J Psychiatry 1991; 33: 149–150.

    Google Scholar 

  6. Hanno R, Beck R. Tuberous sclerosis.Neurol Clin 1987; 5:351–360.

    PubMed  CAS  Google Scholar 

  7. Deonna T, Ziegler AL, Mouraserra J, Innocenti G. Autistic regression in relation to limbic pathology and epilepsy: Report of two cases.Dev Med Child Neurol 1993; 35:166–176.

    PubMed  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sitholey, P., Aga, V.M., Agarwal, V. et al. Childhood autism in tuberous sclerosis. Indian J Pediatr 65, 615–617 (1998). https://doi.org/10.1007/BF02730908

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02730908

Key words

  • Tuberous sclerosis
  • Childhood autism