Skip to main content
SpringerLink
Log in

Losartan induced fetal toxicity

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Losartan is a specific angiotensin II receptor antagonist. Although the teratogenic effects of angiotensin converting enzyme (ACE) inhibitors are well documented there are limited reports of losartan induced fetal toxicity. The authors report a case of incomplete ossification of skull bones, transient oliguria and feed intolerance in a newborn followinginutero exposure to losartan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Saji H, Yamanaker M, Hagiwara A, Jjeri R. Losartan and fetal toxic effects.Lancet 2001; 357:363.

    Article  PubMed  CAS  Google Scholar 

  2. Sorensen AM, Christensen S, Jonassen TE, Andersen D, Petersen JS. Teratogenic effects of ACE-inhibitors and Angiotensin II receptor antagonists (Article in Danish).Ugeker Laegar Mar 2; 160(1) : 1460–1464.

  3. Stevenson KM, Gibson KJ, Lumbers ER. Effects of Losartan on the cardiovascular system, renal haemodynamics and function and lung liquid flow in fetal sheep.Clin Exp Pharmacol Physiol 1996; 23:125–133.

    Article  PubMed  CAS  Google Scholar 

  4. Lambot MA, Vermeyten D, Noel JC. Angiotensin-II receptor inhibitors in pregnancy.Lancet 2001; 357:1619–1620.

    Article  PubMed  CAS  Google Scholar 

  5. Hinsberger A, Wingen AM, Hoyer PF. Angiotensin II receptor inhibitors in pregnancy.Lancet 2001; 357:1620.

    Article  PubMed  CAS  Google Scholar 

  6. Chung NA, Lip GHH, Beevers M, Beevers DG. Angiotensin II receptor inhibitors in pregnancy.Lancet 2001; 357:1620.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India

    Bonilla Nayar, Ashwani Singhal, Rajiv Aggarwal & Neena Malhotra (Assistant Professor)

Authors
  1. Bonilla Nayar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ashwani Singhal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rajiv Aggarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neena Malhotra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neena Malhotra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nayar, B., Singhal, A., Aggarwal, R. et al. Losartan induced fetal toxicity. Indian J Pediatr 70, 923–924 (2003). https://doi.org/10.1007/BF02730601

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02730601

Key words

Search

Navigation