Abstract
A 1 1/2-month-old baby with seizures, lethargy and refusal of feeds was diagnosed to have intracranial hemorrhage due to factor VII deficiency. MRI also demonstrated the unusual presence of a hemorrhagic infarct. The case underscores the importance of carrying out neuroimaging and appropriate hematological studies even in the absence of obvious external bleeding. Hypothesis for increased propensity for intra-cranial hemorrhage is discussed.
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References
Hilgartner MW, Corrigan Jr. JJ. Coagulation disorders. In Miller DR, eds.Blood Diseases of Infancy and Childhood, St Louis, Mosby Year Book, Inc 1995; 924–986.
Papa ML, Schisano G, Franco A, Nina P. Congenital deficiency of factor VII in subarachnoid hemorrhage.Stroke 1994; 25: 508–510.
Sikka M, Gomber S, Madan N, Rusia U, Sharma S. Congenital deficiency of factor VII.Ind J Pediatr 1996; 63: 571–573.
Jain SC, Quadri MI, Garewal G, Bhakoo ON, Das KC. Congenital deficiency of factor VII. Case report of nonidentical twins.Ind Pediatr 1980; 17: 901–905.
Ingerslev J, Kristensen HL. Clinical picture and treatment strategies in factor VII deficiency.Hemophilia 1998; 4: 689–696.
Mazzucconi MG, Mariani G, Chistolini A, Lasagni RP, Motta M, Ghirardini Aet al. Evaluation of thenature of mildly prolonged prothrombin time.Am J hematol 197; 24 : 37–45.
Roberts HR, Hoffman M. Hemophilia and related conditions-Inherited deficiencies of prothrombin (factor II), V and factors VII to XII In Beutler E, Lichtman MA, Coller BS, Kipps TJ, eds.Williams Hematology, 5th Ed New York, McGraw Hill, Inc, 1995 1413–1439.
Matthay KK, Koerper MA, Ablin AR. Interacrtanial hemorrhage in congenital factor VII deficiency.J Pediatr 1979; 94: 413–415.
Bhavanani M, Evans DI. Carries of factor VII deficiency are not always asymptomatic. Clin L: abHaematol 1984; 6: 363–368.
Rotoli B, D’ A vino R, Chiurazzi F. Combined factor V and factor VII deficiency. Report of a case with a record on combined defects and considerations on the relevance of partial deficiency of coagulation factors.Acta Haematol 1983; 69: 117–122.
Girolami A, Venturelli R, Cella G. Virgolini L, Burul A. Combined hereditary deficiency of factors VII and VIII: a distinct coagulation disorder due to the lack of an autosomal gene controlling factor VII and VIII activation.Acta Heamatol 1976; 55: 181–191.
Gorolami G, Dal Bo Zanon R, De Marco L, Cappellato G. Hemophilia B with associated factor VII deficiency: a distinct variant of hemophilia B with low factor VII activity and normal factor VII antigen.Blut 1980; 40: 267–273.
Girolami A, Pontara E, Dannhauser D, Bertomoro A, Ferasin S, Piccolo M et al. First report of combined factor VII Padua defect and type I Von Willebrand disease due to casual association of the two defects.Blood Coagul Fibrinolysis 1993; 4: 177–181.
Lefrere JJ, Chaunu MP, Conard J, Horellou MH, Samama M. Congenital factor VII deficiency and cerebrovascular stroke.Lancet 1985; 8462: 1006–1007.
Wong WT, Huang WC, Miller R, Mc Ginty K, Whisnant JK. Clinical efficacy and recovery levels of recombinant factor VII a (Novoseven) in the treatment of intracranial hemorrhage in severe factor VII deficiency.Hemophilia 2000; 6: 50–54.
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Sanghvi, J.P., Muranjan, M.N., Bavdekar, S.B. et al. Congenital factor VII deficiency. Indian J Pediatr 71, 441–443 (2004). https://doi.org/10.1007/BF02725637
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DOI: https://doi.org/10.1007/BF02725637