Abstract
The authors present two children who had fever ≥38.9°C, diffuse rash, hypotension, deranged renal and hepatic functions, disseminated intravascular coagulation, altered sensorium and inflamed oral mucosa. They responded to fluids, inotropes, antibiotics and intravenous immunoglobulin (2 g/kg). Desquamation particularly of palms and soles and periungal region was noted 1 to 2 weeks after onset of illness. These features were consistent with the diagnosis of staphylococcal toxic shock syndrome (TSS). The cases highlight that TSS is very much with us and can mimic a variety of other diseases. Early recognition, and aggressive antimicrobial supportive and IVIG therapy cover can ensure complete recovery
References
Todd J, Fishaut M, Kapral F, Welch T. Toxic-shock syndrome associated with phage group I Staphylococci.Lancet 1978; 2: 1116–1118.
Schrock CG. Disease alert. (Letter)JAMA 1980; 243(12): 1231.
Silver MA, Simon GL. Toxic shock syndrome in a male postoperative patient.J Trauma 1981; 21: 650–651.
Reingold AL, Hargrett NT, Dan BBet al. Nonmenstruating toxic shock syndrome: Review of 130 cases.Ann Intern Med 1982; 96: 871–874.
Wiesenthal AM, Todd JK. Toxic shock syndrome in children aged 10 years or less.Pediatrics 1984; 74: 112–117.
Greenman RL, Immerman RP. Toxic shock syndrome: what we have learned?Postgrad Med 1987; 81(4): 147–160.
Manders SM. Toxin-mediated streptococcal and staphylococcal disease.J Am Acad Dermatol 1998; 39(3): 383–398.
Issa NC, Thompson RL. Staphylococcal toxic shock syndrome-suspicion and prevention are keys to control.Postgrad Med 2001; 110(4): 59–62.
Todd JK. Staphylococcal infections-Toxic shock syndrome. In Behrman RE, Kliegman RM and Jenson HB eds.Nelson Textbook of Pediatrics. 16th Edition, WB Saunders. 2000; 797–798.
Davis JP, Chesney PJ, Wand PJet al. Toxic-shock syndrome: epidepmiologic features, recurrence, risk factors, and prevention.N Engl J Med 1980; 303(25) : 1429–1435.
Barry W, Hudgins L, Donta ST, Pesanti EL. Intravenous immunoglobulin therapy for toxic shock syndrome.JAMA 1992; 267: 3315–3316.
Davis J, Vergeront J, and Chesney PJ. Possible host defense mechanisms in toxic shock syndrome.Ann Intern Med 1982; 96: 986–991.
Davies HD, Kirk V, Jadavji T, Kotzin BL. Simultaneous presentation of Kawasaki disease and toxic shock syndrome in an adolescent male.Pediatr Infect Dis J 1996; 15(12): 1136–1138.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dass, R., Nishad, P. & Singhi, S. Toxic shock syndrome. Indian J Pediatr 71, 433–435 (2004). https://doi.org/10.1007/BF02725635
Issue Date:
DOI: https://doi.org/10.1007/BF02725635