The Indian Journal of Pediatrics

, Volume 71, Issue 3, pp 229–239 | Cite as

Antibacterial resistance

  • Jocelyn Y. Ang
  • Elias Ezike
  • Basim I. Asmar
Symposium on Infections-Old and New-II


Resistance to antimicrobial agents, whicl was recognized more than 50 years, continues to be a major cause of increased morbidity, mortality and health care cost. Overuse of antibiotics is considered the major contributing factor; however, poor implementation of infection control measures, prolonged hospitalization, admission to intensive care units and the use of invasive procedures are other contributing factors. The authors review the epidemiology, mechanism of resistance, treatment options and prevention measures of infections caused multi-drug resistant S.pneumoniae, methicillin-resistantS. aureus (MRSA), macrolide-resistantS. pyogenes and vancomycin-resistant enterococci (VRE) in pediatric patients. Antibacterial resistance among Gram-negative organisms, including extended spectrum beta-lactamase (ESBL) producing enteric bacteria, and the management and prevention of infections caused by these organisms are also discussed.

Key words

Penicillinnonsusceptible S. pneumoniae Methicillinresistant S. aureus (MRSA) Vancomycinresistantenterococci (VRE) Extended spectrum betalactamase (ESBL) producers 


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Copyright information

© Dr. K C Chaudhuri Foundation 2004

Authors and Affiliations

  • Jocelyn Y. Ang
    • 1
    • 2
  • Elias Ezike
    • 1
    • 2
  • Basim I. Asmar
    • 1
    • 2
  1. 1.Division of Infectious DiseasesChildren’s Hospital of Michigan, Detroit Medical CenterDetroitUSA
  2. 2.Department of Pediatrics School of MedicineWayne State UniversityDetroitUSA

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