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Diagnostic dilemmas in fulminant subacute sclerosing panencephalitis (SSPE)

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Abstract

This report describes an eleven-year-old boy with atypical features of subacute sclerosing panencephalitis (SSPE), a rare complication of measles. He had only visual symptoms for 2 months followed by rapid neurological worsening to a vegetative state in 10 days. A diagnosis of SSPE was made based on the history of measles, characteristic ocular findings, compatible magnetic resonance imaging and electroencephalographic changes, and elevated ratio of cerebrospinal fluid to serum anti-measles antibody titers

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References

  1. Garg RK, Karak B, Sharma AM. Subacute sclerosing panencephalitis.Indian Pediatr 1998; 35: 337–344.

    PubMed  CAS  Google Scholar 

  2. Saha V, John J, Mukundan Pet al. High incidence of subacute sclerosing panencephalitis in South India.Epidemiol Infect 1990; 104:151–156.

    Article  PubMed  CAS  Google Scholar 

  3. Dyken PR. Subacute sclerosing panencephalitis.Neurol Clin 1985; 3:179–185.

    PubMed  CAS  Google Scholar 

  4. Dimova P, Bojinova V. Subacute sclerosing panencephalitis with atypical onset: clinical, computed tomographic and magnetic resonance imaging correlations.J Child Neurol 2000; 15:258–260.

    PubMed  CAS  Google Scholar 

  5. Park DW, Boldt HC, Maskotte SJet al. Subacute sclerosing panencephalitis manifesting as viral retinitis: clinical and histopathologic findings.Am J Ophthalmol 1997; 123:533–542.

    PubMed  CAS  Google Scholar 

  6. Tandon R, Khanna S, Sharma MCet al. Subacute sclerosing panencephalitis presenting as optic neuritis.Indian J Ophthal 1999; 47:250–252.

    CAS  Google Scholar 

  7. Sharma S, Sawhney IMS, Lal Vet al. Subacute sclerosing panencephalitis presenting as cortical blindness.JAPI 1995; 43:434.

    PubMed  CAS  Google Scholar 

  8. Kabra SK, Bagga A, Shankar V. Subacute sclerosing panencephalitis presenting as cortical blindness.Trop Doct 1992; 22:94–95.

    PubMed  CAS  Google Scholar 

  9. Salmon JF, Lee Pan E, Murray ADN. Visual loss with dancing extremities and mental disturbances.Survey Ophthalmol 1991; 35:299–306.

    Article  CAS  Google Scholar 

  10. Kloucek F, Otradovec J. Hestopathological form of central chorioretinal changes in subacute sclerosing leukoencephalitis (Van Bogaert).Ophthalmelogiea 1969; 157:442–450.

    Article  CAS  Google Scholar 

  11. Meyer E, Majlin M, Zonis S. Subacute sclerosing panencephalitis: clinicopathological study of the eyes.J Ophthalmol Pediatr Strabismus 1978; 15:19–23.

    CAS  Google Scholar 

  12. Zagami AS, Lethlean AK. Chorioretinitis as a possible very early manifestation of Subacute sclerosing panencephalitis.Aust NZ J Med 1991; 21:350–352.

    CAS  Google Scholar 

  13. Jabbour JT, Duenas DA, Modlin Jet al. Clinical staging, course and frequency.Arch Neurol 1975; 32: 493–494.

    Google Scholar 

  14. Takayama SY, Iwasaki H, Yamanouchi Ket al. Characteristic clinical features in a case of fulminant subacute sclerosing panencephalitis.Brain Dev 1994; 16:132–135.

    Article  PubMed  CAS  Google Scholar 

  15. Wirguin I, Steiner D, Kidron Tet al. Fulminant subacute sclerosing panencephalitis in association with pregnancy.Arch Neurol 1988; 45:1324–1325.

    PubMed  CAS  Google Scholar 

  16. Broor S, Pal SR, Banerjee AK, et al. Virological and pathological study of subacute sclerosing pan-encephalitis.Indian J Med Res 1975; 63: 671–677.

    PubMed  CAS  Google Scholar 

  17. Broor S, Pal SR, Banerjee AKet al. Subacute sclerosing panencephalitis in Chandigarh.Ind J Med Res 1979; 70: 536–544.

    CAS  Google Scholar 

  18. Cherian T, Joseph A, John TJ. Low antibody response in infants with measles and children with subclinical measles virus infection.J Trop Med Hyg 1984; 87: 27–31.

    PubMed  CAS  Google Scholar 

  19. Anlar B, Saatchi I, Kose Get al. MRI findings in Subacute sclerosing panencephalitis.Neurology 1996; 47:1278–1283.

    PubMed  CAS  Google Scholar 

  20. Tuncay R, Akman- Demir G, Gokyigit Aet al. MRI in subacute sclerosing panencephalitis.Neuroradiology 1996; 38: 636–640.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India

    Lalit Dar & Shobha Broor

  2. Department of Pediatrics, All India Institute of Medical Sciences, 110029, New Delhi, India

    Nupur Sarkar, Sheffali Gulati, Lalit Dar, Shobha Broor &  Veena Kalra (Head)

Authors
  1. Nupur Sarkar
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  2. Sheffali Gulati
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  3. Lalit Dar
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  4. Shobha Broor
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  5. Veena Kalra
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Correspondence to Veena Kalra.

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Sarkar, N., Gulati, S., Dar, L. et al. Diagnostic dilemmas in fulminant subacute sclerosing panencephalitis (SSPE). Indian J Pediatr 71, 365–367 (2004). https://doi.org/10.1007/BF02724111

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