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Nerve conduction in children suffering Insulin Dependent Diabetes Mellitus

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Abstract

Objective: To determine the incidence of peripheral neuropathy in children suffering Insulin Dependent Diabetes Mellitus (IDDM) as well as to determine the relationship between other criteria of the disease and neuropathy.Methods : 40 children (17 males, mean age 11.9 years) suffering IDDM and receiving insulin therapy involving two injections a day and 30 healthy children (17 males, mean age 11.7 years) were included in the study. They were inquired about their demographical characteristics as well as the presence of neurological symptoms. Their detailed neurological examinations were conducted. Their glycemic control values (Hb A1C) were recorded, and their nerve conduction studies were performed from right upper and lower extremities.Results : All nerve conduction values of children with IDDM were found to be significantly lower (p <0.0001) as compared to the control group. 60% of diabetic children (n=24) were found to suffer peripheral neuropathy. Statistically significant relationships were found between the glycemic control values and the peroneal, sural, tibial, ulnar and median nerve conduction velocities, and also between the duration of disease and the peroneal, sural, tibial and median nerve conduction velocities.Conclusion : The peripheral neuropathy is rather a frequently observed complication in diabetic children. The duration of disease and impaired glycemic control play an important role in the development of neuropathy. The introduction of new methods designed to ensure better glycemic control will reduce the incidence of the complication.

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References

  1. Gortmaker SL, Sappenfield W. Chronic childhood disorders. Prevalence and impact.Pediatr Clin North Am 1984;31:3–18.

    PubMed  CAS  Google Scholar 

  2. Vinicor F. Is diabetes a public health disorder?Diabetes Care 1994; 17 (suppl)1: 22–27.

    Google Scholar 

  3. Tietz NW, Finley PR, Pruden EL, eds. Clinical Guide to Laboratory Tests (2nd ed). Philadelphia, W.B. Saunders Company, 1990; 468–475.

    Google Scholar 

  4. Jarausch J, Lotz J, Hafner G Altri. Reference values for the Tinaquant HbAlC Assay.Clin Chem 1996;42: 116 (Abstract 094).

    Google Scholar 

  5. Bosch EP, Smith BE. Disorders of Peripheral Nerves. In Bradley WG, Daroff RB, Fenichel GM, Marsden CD, ed.Neurology in Clinical Practice The Neurological Disorders. Boston, Butterworth-Heinemann 2000; 2097–2103.

    Google Scholar 

  6. Walters DP, Gatling W, Mullee MA, Hill RD. The Prevalence of diabetic distal sensory neuropathy in an English community.Diabet Med 1992; 9(4): 349–353.

    PubMed  CAS  Google Scholar 

  7. Boa XH, Wong V, Wang Q, Low LC. Prevalence of peripheral neuropathy with insulin-dependent diabetes mellitus.Pediatr Neurol 1999; 20(3): 204–209.

    Article  Google Scholar 

  8. Gallai V, Firenze C, Mazzotta, Del Gatto F. Neuropathy in children and adolescents with diabetes mellitus.Acta Neurol Scand, 1988; 78:136–140.

    Article  PubMed  CAS  Google Scholar 

  9. Young RJ, Ewing D, Clarke BF. Nerve function and metabolic control in teenage diabetics.Diabetes 1983; 32:142–147.

    Article  PubMed  CAS  Google Scholar 

  10. Fýçýcýoðlu C, Aydýn A, Haktan M, Kýzýltan M. Peripheral Neuropathy in Children with ’Ynsulin-Dependent Diabetes Mellitus.The Turkish Journal of Pediatrics 1994; 36:97–104.

    Google Scholar 

  11. Comi G, Canal N, Lozza Let al. Peripheral Nerve Abnormalities in Newly-Diagnosed Diabetic Children.Acta Diabetol Lat 1986; 23: 69–75.

    Article  PubMed  CAS  Google Scholar 

  12. Tesfaye S, Stevens LK, Stephenson JMet al. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors.Diabetologia 1996; 39: 1377–1384.

    Article  PubMed  CAS  Google Scholar 

  13. Kaar ML, Saukkonen AL, Pitkanen M, Akerblom HK Peripheral neuropathy in diabetic children and adolescents.Acta Pediatr Scand 1983; 72: 373–378.

    CAS  Google Scholar 

  14. Eng GD, Hung W, August GP, Smokvina MD. Nerve conduction velocity determinations in juvenile diabetes: Continuing study of 190 patients.Arch Phys Med Rehabil 1976; 57 (1): 1–5.

    PubMed  CAS  Google Scholar 

  15. Moglia A, Lorini R, D’Annunzyo G, Lanzi G, Berardinelli A, Zandrini C. Clinical and neurophysiological study in diabetic children and adolescents.Funct Neurol 1994; 9 (2): 75–82.

    PubMed  CAS  Google Scholar 

  16. Allen C, Shen G, Palta M, Lotz B, Jacobson R, D’Alessio D. Long-term hyperglycemia is related to peripheral nerve changes at a diabetes duration of 4 years. The Wisconsin Diabetes Registry.Diabetes Care 1997; 20 (7): 1154–1158.

    Article  PubMed  CAS  Google Scholar 

  17. Ludvigsson J, Johonnesson G, Heding L, Hager A, Larsson Y. Sensory Nerve Conduction velocity and Vibratory Sensibility in Juvenile Diabetics.Acta Pediatr Scand 1979; 68: 739–743.

    CAS  Google Scholar 

  18. Porte D, Graf RJ, Halter JB, Pfeifer MA, Halar E. Diabetic Neuropathy and Plasma Glucose Control.Am J Med 1981; 70: 195–200.

    Article  PubMed  Google Scholar 

  19. Amthor KF, Jorgensen KD, Berg TJet al. The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: The Oslo Study.Diabetologia 1994; 37: 579–584.

    PubMed  CAS  Google Scholar 

  20. Solders G, Thalme B, Aquino MA, Brandt L, Berg U, Persson A. Nerve conduction and autonomic nerve function in diabetic children. A 10-year follow-up study.Acta Paediatr 1997; 86: 361–366.

    PubMed  CAS  Google Scholar 

  21. Gregersen G. Diabetic neuropathy: Influence of age, sex, metabolic control, and duration of diabetes on motor conduction velocity.Neurology 1967; 17: 972–980.

    PubMed  CAS  Google Scholar 

  22. Bertelsmann FW, Heimans JJ, Van Rooy JC, Popp-Snijders C, Van der Veen EA. Peripheral nerve function in relation to quality of metabolic control in diabetes.Neurology 1987; 234(5): 334–336.

    Article  CAS  Google Scholar 

  23. Barkai L, Kempler P, Vamosi L, Lukacs K, Marton A, Keresztes K. Peripheral Sensory nerve dysfunction in children and adolescants with type I diabetes mellitus.Diabet Med 1998; 15 (3): 228–233.

    Article  PubMed  CAS  Google Scholar 

  24. Reichard P, Britz A, Carlsson Pet al. Metabolic control and complications over 3 years in patients with insulin dependent diabetes (IDDM): the Stockholm Diabetes Intervention Study (SDK).J Intern Med 1990; 228 (5): 511–517.

    Article  PubMed  CAS  Google Scholar 

  25. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulin-dependent diabetes mellitus.N Engl J Med 1993; 329 (14): 977–986.

    Article  Google Scholar 

  26. Verrotti A, Catino M, Ricco L, Casani A, Chiarelli F. Prevention of microvasc:uler complications in diabetic children and adolescents.Acta Pediatr (Suppl.) 1999; 427: 35–38.

    Google Scholar 

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Author notes

  1. Birkan Sonel Tur & Yavuz Gurer

    Present address: Department of Physical Medicine and Rehabilitation, Ankara University, School of Medicine, Ankara, Turkey

Authors and Affiliations

  1. Department of Pediatric Endocrinology, Dr. Sami Ulus Children Health and Diseases Training and Research Hospital, Turkey

    Funda Cenesiz & Tahsin Tezic

  2. Department of Pediatric Neurology, Ankara University, School of Medicine, Ankara, Turkey

    Birkan Sonel Tur & Yavuz Gurer

  3. Department of Physical Medicine and Rehabilitation, Ankara University, School of Medicine, Ankara, Turkey

    Funda Cenesiz & Tahsin Tezic

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  1. Funda Cenesiz
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  2. Birkan Sonel Tur
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  4. Yavuz Gurer
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Correspondence to Funda Cenesiz.

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Cenesiz, F., Tur, B.S., Tezic, T. et al. Nerve conduction in children suffering Insulin Dependent Diabetes Mellitus. Indian J Pediatr 70, 945–951 (2003). https://doi.org/10.1007/BF02723816

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