Abstract
Objective : There is limited data available on symptomatic leptospirosis in Indian children. We report an outbreak of leptospirosis that occurred in children living in slums following heavy rainfall and flooding. This hospital — based prospective study was conducted from July to August 2001.Methods : Diagnosis of acute leptospirosis was suspected by following the Indian Leptospirosis Society working definition for leptospirosis. Diagnosis was confirmed by detecting anti —Leptospira antibodies, using either aLeptospira genus — specific latex agglutination assay or a dipstick assay or by a macroscopic slide agglutination test.Result : Thirty (32%) out of 93 children admitted had acute leptospirosis. Fever, bodyache, chills, abdominal pain, headache, vomiting, cough, hepatosplenomegaly, edema and crepitations were the common presenting signs and symptoms. Twenty — two children had anicteric leptospirosis and 8 had Weil disease. Response to penicillin treatment was good in all except in one child with Weil disease who died of renal failure within 3 hours of admission.Conclusion : Leptospirosis has emerged as an infectious disease in Mumbai. During monsoon, parents should ensure that their child does not have contact with the contaminated flood water.
This is a preview of subscription content, access via your institution.
References
Feigin RD, Anderson DC. Leptospirosis. In Feigin RD, Cherry JD, eds.Textbook of Pediatric Infectious Diseases. Philadelphia; Saunders; 1998; 1529–1542.
Farr R.W. Leptospirosis.Clin Infect Dis 1995; 21: 1–8.
Marotto PCF, Marotto MS, Santos DL, Souza TNL, Seguro AC. Outcome of leptospirosis in children.Am J Trop Med Hyg 1997; 56: 307–310.
World Health Organization. Leptospirosis worldwide.Wkly Epidemiol Rec 1999; 74: 237–242.
Muthusethupathi MA, Shivakumar S, Suguna R, Jayakumar M, Vijayakumar R, Everard CORet al. Leptospirosis in Madras — a clinical and serological study.J Assoc Physicians India 1995; 43: 456–458.
Kuriakose M, Eapen CK, Paul R. Leptospirosis in Kolenchery, Kerala, India: epidemiology, prevalent local serogroups and serovars and a new serovar.Eur J Epidemiol 1997; 13 : 691–697.
Singh SS, Vijayachari P, Sinha A, Sugunan AP, Rasheed MA, Sehgal SC. Clinico — epidemiological study of hospitalized cases of severe leptospirosis.Indian J Med Res 1999; 109: 94–99.
Sehgal SC, Vijayachari P, Murhekar MV, Sugunan AP, Sharma S, Singh SS. Leptospiral infection among primitive tribes of Andaman and Nicobar Islands.Epidemiol Infect 1999; 122: 423–428.
World Health Organization. Leptospirosis, India. Report of the investigation of a post-cyclone outbreak in Orissa, November 1999.Wkly Epidemiol Rec 2000; 75: 217–223.
Shah I, Warke S, Deshmukh CT, Kamat JR. Leptospirosis — an under-diagnosed clinical condition.J Postgrad Med 1999; 45: 93–94.
Sehgal SC. Recommendations of national symposium on leptospirosis.Indian J Med Microbiol 1997; 15: 211–212.
Ko AI, Reis MG, Dourado CR, Johnson WD Jr, Riley LW. Salvador Leptospirosis Study Group. Urban epidemic of severe leptospirosis in Brazil.Lancet 1999; 354: 820–825.
World Health Organization. Guidelines for the Control of Leptospirosis. In Faine S, ed.WHO Offset Publication No.67. Geneva: World Health Organization, 1982; 1–171.
De A, Varaiya A, Pujari A, Mathur M, Bhatt M, Karande Set al. An outbreak of leptospirosis in Mumbai.Indian J Med Microbiol 2002; 20: 153–155.
Vinetz JM, Glass GE, Flexner CE, Mueller P, Kaslow DC. Sporadic urban leptospirosis.Ann Intern Med 1996; 125: 794–798.
Myers DM. Leptospiral antibodies in stray dogs of Moreno, Province of Buenos Aires, Argentina.Rev Argent Microbiol 1980; 12: 18–22.
Dalai PM. Leptospirosis in Bombay. Report of five cases.Indian J Med Sci 1960; 14: 295–301.
Smits HL, van der Hoorn MA, Goris MG, Gussenhoven GC, Yersin C, Sasaki DMet al. Simple latex agglutination assay for rapid serodiagnosis of human leptospirosis.J Clin Microbiol 2000; 38: 1272–1275.
Sehgal SC, Vijayachari P, Sharma S, Sugunan AP. LEPTO Dipstick: a rapid and simple method for serodiagnosis of acute leptospirosis.Trans R Soc Trop Med Hyg 1999; 93: 161–164.
Brandao AP, Camargo ED, da Silva ED, Silva MV, Abrao RV. Macroscopic agglutination test for rapid diagnosis of human leptospirosis.Clin Microbiol 1998; 36: 3138–3142.
Silva MV, Camargo ED, Batista L, Vaz AJ, Brandao AP, Nakamura PMet al. Behaviour of specific IgM, IgG and IgA class antibodies in human leptospirosis during the acute phase of the disease and during convalescence.J Trop Med Hyg 1995; 98: 268–272.
Turner LH. Leptospirosis.Br Med J 1969; i: 231–235.
Anonymous. BMC rolls up its sleeves to tackle spread of leptospirosis.The Times of India, Mumbai 2002 Jan 19; 2 (col.4). Available at: http://www.timesofindia.com/ Accessed Feb 4, 2002.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Karande, S., Kulkarni, H., Kulkarni, M. et al. Leptospirosis in children in Mumbai slums. Indian J Pediatr 69, 855–858 (2002). https://doi.org/10.1007/BF02723705
Issue Date:
DOI: https://doi.org/10.1007/BF02723705