Skip to main content
Log in

Serum zinc and copper levels in the maternal blood and cord blood of neonates

  • Original Article
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Estimation of serum zinc and copper in the maternal blood and cord blood of neonates was carried out to correlate the trace metals in the neonates and their mothers in relation to gestational age and birth weight. Sixty-five healthy neonates, both term and preterm and their mothers were selected. This cross sectional study was done at Azimpur Maternity Centre, Dhaka Medical College Hospital and Chemistry Division, Atomic Energy Centre, Dhaka, Bangladesh from July 1997 to June 1998. The estimation of trace metals was carried out by Atomic Absorption Spectrophotometry (AAS). The mean serum zinc levels in the maternal blood and cord blood were 0.47 ± 0.24 μg/ml and 0.85 ± 0.33 μg/ml respectively and the mean copper levels in the maternal blood and cord blood were 1.37 ± 0.62 μg/ml and 0.31 ± 0.32 μg/ml respectively. Cord blood zinc level was significantly higher and cord blood copper level was significantly lower than the corresponding maternal blood levels. There was no significant correlation between gestational age and serum zinc levels in the cord or maternal blood. But significant inverse correlation was found between gestational age and serum levels of copper in the maternal and cord blood.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Aggett PJ. Aspects of neonatal metabolism of trace metals.Acta Pediatric Suppl 1994; 402: 75–82.

    CAS  Google Scholar 

  2. Simmer K, Ahmed S, Carlsson L, Thompson RPH. Breast milk and copper concentrations in Bangladesh.Br J Nutr 1990; 63: 91–96.

    Article  PubMed  CAS  Google Scholar 

  3. Roy SK, Behrent RH, Thomkins AM. Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhea and persistent diarrhea syndrome.J Pediatr Gastroenterol Nutr 1992; 15: 289–296.

    Article  PubMed  CAS  Google Scholar 

  4. Fanaroff AA, Martin RJ, eds.Diseases of the Fetus and Infants. St. Louis; Mosby Co, 1987; 1077–1093,1263.

    Google Scholar 

  5. Atinmo T, Mbofung C, Osinusi BO. Relationship of zinc and copper concentrations in maternal and cord blood and birth weight.Int J Gynaecol Obstet 1980; 18: 452–454.

    PubMed  CAS  Google Scholar 

  6. Jeswani RM, Vani SN. A study of serum zinc levels in cord blood of neonates and their mothers.Indian J Pediatr 1991; 58: 683–687.

    PubMed  CAS  Google Scholar 

  7. Islam MA, Hemalatha P, Bhaskaram P, Kumar PA. Leukocyte and plasma zinc in maternal and cord blood: their relationship to period of gestation and birth weight.Nutr Res 1994; 14: 353–360.

    Article  CAS  Google Scholar 

  8. Henkin IR, Marshal JR, Meret S. Maternofetal metabolism of copper and zinc at term.Am J Obstet Gynecol 1971; 110: 131–134.

    PubMed  CAS  Google Scholar 

  9. Swanson CA, King JC. Reduced serum zinc concentration during pregnancy.Obstet Gynecol 1983; 62: 313–316.

    Article  PubMed  CAS  Google Scholar 

  10. Meadows NJ, Ruse W, Smith MFet al. Zinc and small babies.Lancet 1981; 2: 1135–1136.

    Article  PubMed  CAS  Google Scholar 

  11. Kapoor KK, Mirsa PK, Dixit Set al. Zinc and intrauterine growth.Indian Pediatr 1988; 25: 972–976.

    PubMed  CAS  Google Scholar 

  12. Prasad LSN, Ganguly S, Vasuki K. Role of zinc in fetal nutrition.Indian Pediatr 1974; 11: 799–802.

    PubMed  CAS  Google Scholar 

  13. Wasowicz W, Wolkanin P, Bendnarski Met al. Plasma trace element (Se, Zn, Cu) concentrations in maternal and umbilical cord blood in Poland [abstract].Biol Trace Elem Res 1993; 38: 205–215.

    PubMed  CAS  Google Scholar 

  14. O’Leary JA, Novalis GSVosburgh GJ. Maternal serum copper concentrations in normal and abnormal gestations.Obstet Gynecol 1966; 28: 112–116.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. S. M. Iqbal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iqbal, A.S.M., Shahidullah, M., Islam, M.N. et al. Serum zinc and copper levels in the maternal blood and cord blood of neonates. Indian J Pediatr 68, 523–526 (2001). https://doi.org/10.1007/BF02723246

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02723246

Key words

Navigation