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Miltefosine: An oral drug for visceral leishmaniasis

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Abstract

Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmaniain vitro and animal model. 1,2 Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.

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References

  1. Croft SL, Neal RA, Pendergast W, Chan JH. The activity of alkylphosphocholines and related deravatives against Leishmania donovani. Biochemical Parasitai 1987; 2633–2636.

  2. Kuhlencord A, Maniera T, Eibl H, Unger C. Hexadecyl Phosphocholine; oral treatment of visceral leishmaniasis in mice. Antimicrobial agents and Chemotherapy 1992; 36: 1630–1634.

    PubMed  CAS  Google Scholar 

  3. Bora D. Epidemiology of visceral leishmaniasis in India.Nat Med J India 1999; 12: 62–67.

    CAS  Google Scholar 

  4. Anon, 1998. Tropical Diseases Reaserch Progress 1997–1998, Fourteenth Programme Report — Leishmaniasis, PP. 1–22.

  5. Jendrossek V, Handrick R. Mmebrane Targeted Anticancer Drugs: Potent Ihducer of Apoptosis and putative Radiosesis.Curr med Chem Anti-Cane Agents 2003; 3(5): 343–353.

    Article  CAS  Google Scholar 

  6. Sunder S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, Junge K, Bryceson A, Berman J. Oral Miltefosine for Indian Visceral leishmaniasis.N Engl J Med 2002; 347: 1739–1746.

    Article  Google Scholar 

  7. Hanson PK, Malone L, Birchmore JL, Nichols JW. Lern 3 p is essential for the uptake and potecy of alkylphosphocholine drugs, edelfosine and miltefosine.J Bid Chem 2003; 5(2): 1324–1331.

    Google Scholar 

  8. Perez-Victoria FJ, Castanys S, Gamaroo F. Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. Antimicrobiol Agents Chemother. 2003; 47: 2397–2403.

    Article  CAS  Google Scholar 

  9. Sunder S, Jha TK, Sindermann H, Bachmann P, Berman J. Oral miltefosine in children with mild to moderate Indian Visceral leishmanisis.Pediatr Infect Dis J 2003; 22(5): 434–438.

    Article  Google Scholar 

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Authors and Affiliations

  1. Sishu Arogya Kendra, Patna

    Ranjeet Kumar

  2. Department of Pediatrics, Nalanda Medical College, Patna, India

    B. P. Jaiswal &  Utpal Kant Singh

  3. Institute of Medical Science, Banaras Hindu University, Varanasi

    Rajniti Prasad, Ranjeet Kumar, B. P. Jaiswal &  Utpal Kant Singh

Authors
  1. Rajniti Prasad
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  2. Ranjeet Kumar
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  3. B. P. Jaiswal
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  4. Utpal Kant Singh
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Prasad, R., Kumar, R., Jaiswal, B.P. et al. Miltefosine: An oral drug for visceral leishmaniasis. Indian J Pediatr 71, 143–144 (2004). https://doi.org/10.1007/BF02723096

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