Skip to main content

Characterization of fibroblast growth factor activity secreted by embryonal carcinoma cells

This is a preview of subscription content, access via your institution.

References

  1. Dickson, C.; Fuller-Pace, F.; Kiefer, P., et al. Expression, processing, and properties of int-2. Ann. NY Acad. Sci. 638:18–26; 1991.

    PubMed  Article  CAS  Google Scholar 

  2. Feldman, B.; Poueymirou, W.; Papaioannou, V. E., et al. Requirement of FGF-4 for postimplantation mouse development. Science 267:246–249; 1995.

    PubMed  Article  CAS  Google Scholar 

  3. Gospodarowicz, D.; Cheng, J. Heparin protects basic and acidic FGF from inactivation. J. Cell Physiol. 128:475–484; 1986.

    PubMed  Article  CAS  Google Scholar 

  4. Gospodarowicz, D.; Bialecki, H.; Greenburg, G. Purification of the fibroblast growth factor activity from bovine brain. J. Biol. Chem. 253:3736–3743; 1978.

    PubMed  CAS  Google Scholar 

  5. Hebert, J. M.; Boyle, M.; Martin, G. R. mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Development 112:407–515; 1991.

    PubMed  CAS  Google Scholar 

  6. Jakobovits, A.; Shackleford, G. M.; Varmus, H. E., et al. Two protooncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc. Natl. Acad. Sci. USA 83:7806–7810; 1986.

    PubMed  Article  CAS  Google Scholar 

  7. Peters, G.; Brookes, S.; Smith, R., et al. The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc. Natl. Acad. Sci. USA 86:5678–5682; 1989.

    PubMed  Article  CAS  Google Scholar 

  8. Rizzino, A.; Bowen-Pope, D. F. Production of PDGF-like growth factors by embryonal carcinoma cells and binding of PDGF to their endoderm-like differentiated cells. Dev. Biol. 110:15–22; 1985.

    PubMed  Article  CAS  Google Scholar 

  9. Rizzino, A.; Ruff, E. Fibroblast growth factor induces the soft agar growth of two non-transformed cell lines. In Vitro Cell. Dev. Biol. 22:749–755; 1986.

    PubMed  Article  CAS  Google Scholar 

  10. Rizzino, A.; Kuszynski, C.; Ruff, E., et al. Production and utilization of growth factors related to fibroblast growth factor by embryonal carcinoma cells and their differentiated cells. Dev. Biol. 129:61–71; 1988.

    PubMed  Article  CAS  Google Scholar 

  11. Saksela, O.; Moscatelli, D.; Sommer, A., et al. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J. Cell Biol. 107:743–751; 1988.

    PubMed  Article  CAS  Google Scholar 

  12. Seo, M.; Noguchi, K. Retinoic acid induces gene expression of fibroblast growth factor-9 during induction of neuronal differentiation of mouse embryonal carcinoma P19 cells. FEBS Lett. 370:231–235; 1995.

    PubMed  Article  CAS  Google Scholar 

  13. Sommer, A.; Rifkin, D. B. Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan. J. Cell Physiol. 138:215–220; 1989.

    PubMed  Article  CAS  Google Scholar 

  14. Tiesman, J.; Rizzino, A. Expression and developmental regulation of the k-FGF oncogene in human murine embryonal carcinoma cells. In Vitro Cell. Dev. Biol. 25:1193–1198; 1989.

    PubMed  Article  CAS  Google Scholar 

  15. Veleich, A.; Delli-Bovi, P.; Mansukhani, A., et al. Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells. Oncogene Res. 5:31–37; 1989.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Miller, K., Rizzino, A. Characterization of fibroblast growth factor activity secreted by embryonal carcinoma cells. In Vitro Cell.Dev.Biol.-Animal 32, 531–533 (1996). https://doi.org/10.1007/BF02722979

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02722979

Keywords

  • Embryonal Carcinoma
  • Mitogenic Activity
  • Embryonal Carcinoma Cell
  • Bovine Calf Serum
  • Thymidine Incorporation Assay