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Mother-to-child transmission of hepatitis E virus infection

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Objectives : Water borne or enterically transmitted non-A-non-B hepatitis is a major public health problem in India. Many of these cases carry fatal outcome. The hepatitis E virus (HEV) has been considered to be the most important causative agent of this entity. The severity and fatality rates of HEV infection are reported to be rather more in pregnant women. However, there is meager information from India, on mother to child transmission of this agent.Methods : During 1997-98, we studied 60 pregnant women suspected to have acute viral hepatitis to understand the frequency of various viral etiologies, disease course and outcome of the pregnancy. Six cord blood samples were tested for IgG, and IgM antibodies against hepatropic viral agents and also for hepatitis E virus RNA by RT-nested PCR using ORF-1 as target.Results : Of the 60 pregnant patients hospitalised at All India Institute of Medical Sciences, New Delhi for acute hepatitis, 22 (37%) were positive for IgM anti-HEV antibodies and 10% were infected with hepatitis B virus. Co-infection of HEV with Hepatitis B and C was seen in 1 and 2 patients, respectively. Most (72%) of the HEV infected patients were in third trimester of pregnancy (P<0.05). Of the 6 cord blood samples tested 3 (50%) were positive for HEV RNA. Though, all mothers were RNA positive, half of the babies did not get infectedin utero with HEV. Fourteen of the 22 (63.6%) HEV infected mothers developed fulminant hepatic failure and all died.Conclusion : The mortality rate in HIV infected mothers was 100%. Mother to child transmission of hepatitis E virus infection was established in 50%

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  1. Arankalle VA, Chadha MS, Tsarev SA, Emerson SU, Risbud A, Banerjee K, Purcell H. Seroepidemiology of water borne hepatitis in India and evidence for a third enterically transmitted hepatitis agent.Proc Natl Acad Sci 1994; 91:3428–3432.

    Article  PubMed  CAS  Google Scholar 

  2. Khuroo MS, Kamili S, Jameel S. Vertical transmission of HEV.Lancet 1995; 345; 1025–1026.

    Article  PubMed  CAS  Google Scholar 

  3. Singh S, Mohanty A, Joshi YK, Deka D, Dwivedi SN. Outcome of hepatitis E virus infection in Indian pregnant women admitted to a tertiary care hospital.Indian J Med Res 2001; 113:35–39.

    Google Scholar 

  4. Ryder SD, Beckingham If. ABC of diseases of liver, pancreas, and biliary system: Acute hepatitis.BMJ 2001 20; 322 (7279) : 151–153.

    Article  Google Scholar 

  5. Panda SK, Nanda SK, Zafarulla M, Ansari IH, Ozdener MH, Jameel S. An Indian strain of hepatitis E virus (HBV): cloning, sequence, and expression of structural region and antibody responses in sera from individuals from an area of high level HEV endemicity.J Clin Microbiol 1995; 33:2653–2659.

    PubMed  CAS  Google Scholar 

  6. Smedile A, Card P, Verma G, Caredda F, Cargael A, Caporaso Net al. Influence of delta infection on severity of hepatitis B.Lancet 1982; ii: 945–947.

    Article  Google Scholar 

  7. Acharya SK, Dasrathy S, Kumar TLet al. Fulminent hepatitis in tropical population: clinical course, cause, and early predictors of outcome.Hepatology 1996; 23:1448–1455.

    Article  PubMed  CAS  Google Scholar 

  8. Van der Poel WHM, Verschoor F, van der Heide Ret al. Hepatitis E virus sequences in Swine related to sequences in humans, the Netherlands.Emerg Infect.Dis 2001; 7:970–976.

    Article  PubMed  Google Scholar 

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Correspondence to Sarman Singh.

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Singh, S., Mohanty, A., Joshi, Y.K. et al. Mother-to-child transmission of hepatitis E virus infection. Indian J Pediatr 70, 37–39 (2003).

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