Abstract
Two hospital delivered full term newborn babies were detected to have cholestatic jaundice in the first week of life. They had raised liver enzyme levels, which gradually declined over a period of one month. Both babies were anti HAV IgM positive on 6th day of life in Case 1 and on 7th day of life in Case 2 respectively. Both the mothers had jaundice 20 and 26 days before delivery and had anti HAV IgM positivity two and three weeks prior to delivery in Case 1 and 2 respectively. Hepatitis A virus is not transmitted vertically from mother to baby. However, there are 3 such case reports in literature stating vertical transmission of HAV infection. We are reporting it in two neonates for the first time in India
References
Krugman S, Ward R, Giles JP. The natural history of infections hepatitis.Am J Med 1962; 32: 717–728.
Hollinger FB, Khan NC, Oefinger Pet al. Post transfusion hepatitis type A.JAMA 1983; 250: 2313–2317.
Mannucci PM, Gdovin S, Gringeri Aet al. Transmission of hepatitis A to patients with hemophilia by factor VII concentrates treated with organic solvent and detergent to inactivate viruses. The Italian collaborative Group.Ann Int Med 1994; 120:1–7.
Fujiwara K, Yokosuka O, Ehata T, Imazeki ‘F’, Saisho H, Miki M, Qmata M. Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A.Hepatology 1997; 26: 1634–1939.
Dienstag JL, Feinstone SM, Kapikian AL, Purcell RH. Fecal shedding of hepatitis A antigen.Lancet 1975; 1: 765–767.
Rakela J, Mosley JW. Fecal excretion of hepatitis A virus in humans.J Infect Dis 1977; 135: 933–938.
Chitambar SD, Joshi MS, Sreenivasan MA, Arankalle VA. Fecal shedding of hepatitis A virus in Indian patients with hepatitis A and in experimentally infected rhesus monkey.Hepatol Res (2000) In Press.
Tong MJ, Thursby M, Rakela J, McPeak C, Edwards VM, Mosley JW. Studies on the maternal-infant transmission of the viruses which cause acute hepatitis.Gastroenterology 1981; 80: 999–1004.
Watson JC, Fleming DW, Borella AJ, Olcott ES, Conrad RE, Baron RC. Vertical transmission of hepatitis A resulting in an outbreak in a neonatal intensive care unit.J infect Dis 1993; 67: 567–571.
Tanaka I, Shima M, Kubota Y, Takahashi Y, Kawamata O, Yoshioka A. Vertical transmission of hepatitis A virus.Lancet 1995; 345: 397.
Erkan T, Kutlu T, Cullu F, Tumay GT. A case of vertical transmission of hepatitis A virus infection.Acta Paediatr 1998; 87:1008–1009.
Noble RC, Kane MA, Reeves SA, Roecket I. Post transfusion hepatitis A in a neonatal intensive care unit.JAMA 1984; 252: 2711–2715.
Syndman DR. Hepatitis in pregency.N Eng J Med 1985; 80: 999–1004.
Balistreri WF. Acute and chronic viral hepatitis. In Suchy FJ, ed.Liver Disease in Children, 1st edn. Mosby, St. Lousi, 1994; 460–509.
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Renge, R.L., Dani, V.S., Chitambar, S.D. et al. Vertical transmission of Hepatitis A. Indian J Pediatr 69, 535–536 (2002). https://doi.org/10.1007/BF02722662
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DOI: https://doi.org/10.1007/BF02722662