Abstract
Role of peripheral and central noradrenaline and 5-hydroxytryptamine in the carrageenin-induced pedal oedema in rats was studied using agents which influence catecholamine synthesis and receptor activity of noradrenaline and 5-hydroxytryptamine. Reserpine, guanethidine, α-methyl-p-tyrosine, diethyldithiocarbamate, 6-hydroxydopamine, phenoxybenzamine, phentolamine, chlorpromazine and yohimbine markedly inhibited carrageenin-induced pedal oedema. However, 6-hydroxydopamine given intracerebroventricularly, 5,6-dihydroxytryptamine,p-chlorophenylalanine, lower dose of yohimbine, pro pranolol, haloperidol, cyproheptadine and mepyramine did not alter the carrageenin-induced oedema, whereas, cyproheptadine and mepyramine given simultaneously, markedly inhibited carrageenin-induced oedema. Our studies indicate that the process of oedema formation in rats by carrageenin involves both the peripheral noradrenaline and 5-hydroxytryptamine
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Abbreviations
- 5-HT:
-
5-Hydroxytryptamine
- i.c.v.:
-
intracerebroventricular
- 6-HD:
-
6-hydroxydopamine
- DHT:
-
5,6-dihydroxytryptamine
- RES:
-
Reserpine
- MPT:
-
α-methyl-p-tyrosine
- DDC:
-
diethyl dithiocarbamate
- GUA:
-
guanethidine
- PCPA:
-
p-chlorophenylalanine
- PHENT:
-
phentolamine
- CPZ:
-
chlorpromazine
- PBZ:
-
phenoxybenzamine
- YOH:
-
yohimbine
- PROP:
-
propranolol
- HALO:
-
haloperidol
- CYP:
-
cyproheptadine
- MEP:
-
mepyramine
- NA:
-
noradrenaline
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Communication No. 58 from IDPL Research Centre, Hyderabad.
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Singh, P.P., Junnarkar, A.Y. & Shridhar, D.R. Involvement of peripheral noradrenaline and 5-hydroxytryptamine in carrageenin-induced pedal oedema in rats. J Biosci 6, 257–261 (1984). https://doi.org/10.1007/BF02716739
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DOI: https://doi.org/10.1007/BF02716739