Abstract
The effects of methylchoranthrene and carrageenan on the lungs of rabbits were studied. Four out of five animal which were injected via the bronchus with a suspension of 100 mg 20-methylchoranthrene in 8 ml solution of 0.75% lambda carrageenan in saline developed emphysematous bullae in the treated lobes of the lungs two months later. Animals treated with carrageenan solution (group 1), a suspension of methylchoranthrene in 10% tween 60 solution (group 2), and saline (group 3), failed to demonstrate cystic lesions in the lungs, except for one animal in group 1. These results suggest that this is a good experimental animal model for emphysematous bullae.
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Mitsuhashi, T., Sugino, S., Shimazaki, M. et al. Experimental emphysematous bullae. Lung 162, 165–170 (1984). https://doi.org/10.1007/BF02715644
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DOI: https://doi.org/10.1007/BF02715644