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Airway smooth muscle and platelet responses to several varieties of cotton bracts

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Abstract

Aqueous extracts of several varieties of cotton bracts were tested for their ability to: (1) contract isolated canine airways, and (2) cause 5-hydroxy-tryptamine (5-HT) release from human platelets. With regard to airway contractions, the order of effectiveness was: Lambright GL-4=Early Cot WR=LX-571>Texas Mix>Acala SJ-2>Coker 310. The EC50 for Coker 310 was approximately 6 times greater than that for Lambright GL-4. With regard to 5-HT release from platelets, the order of effectiveness was: LX-571=Acala SJ-2>Lambright GL-4>Coker 310>Early Cot WR>Texas Mix. The EC50 for Texas Mix was approximately 15 times greater than that for LX-571. There was no correlation between the EC50’s for smooth muscle contraction and the EC50’s for 5-HT release. We conclude that the concentrations of the bronchoactive and platelet active factors vary considerably among bracts obtained from different varieties of cotton. Moreover, bracts that contain a high concentration of the bronchoactive factor do not necessarily contain a high concentration of the platelet active factor, and vice-versa.

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Authors and Affiliations

  1. Department of Pediatrics, State University of New York at Buffalo, 166 Acheson Hall, 14214, Buffalo, New York, USA

    James A. Russell

  2. University of Minnesota, 54455, Minneapolis, Minnesota, USA

    Mark L. Gilberstadt

  3. Mayo Clinic, 55905, Rochester, Minnesota, USA

    Rebecca A. Rolstad & Michael S. Rohrbach

Authors
  1. James A. Russell
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  2. Mark L. Gilberstadt
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  3. Rebecca A. Rolstad
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  4. Michael S. Rohrbach
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Russell, J.A., Gilberstadt, M.L., Rolstad, R.A. et al. Airway smooth muscle and platelet responses to several varieties of cotton bracts. Lung 162, 89–97 (1984). https://doi.org/10.1007/BF02715635

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  • DOI: https://doi.org/10.1007/BF02715635

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