Abstract
To clarify the role of alveolar macrophages (AM) in the development of endotoxin induced lung injury in rats, we examined the release of plasminogen activator (PA) by AM and fibrinolytic activity in the bronchoalveolar lavage (BAL) fluid. An intraperitoneal injection of 5 mg/kg endotoxin was followed by a rapid increase in PA release by AM and corresponding increase in fibrinolytic activity in BAL fluid. These effects reached a maximum 3 h after injection. Within 6 h after injection widening of alveolar-arterial oxygen difference (AaDO2) and increase in alveolar capillary permeability were found. There was significant positive correlation between PA release by AM and fibrinolytic activity in BAL fluid, and also between AaDO2 and fibrinolytic activity in BAL fluid. These results suggest that AM may contribute to the pathogenesis of endotoxin induced lung injury in rats through a PA dependent mechanism.
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Etoh, T., Kakishita, E. & Nagai, K. Role of alveolar macrophage plasminogen activator in the acute pulmonary responses to endotoxin. Lung 162, 49–58 (1984). https://doi.org/10.1007/BF02715627
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DOI: https://doi.org/10.1007/BF02715627