Abstract
To quantitatively examine and compare the breathing patterns during transient and steady state hypoxia, studies were performed repeatedly in five awake, chronic dogs. Transient hypoxia of 30 s was induced with 5–7 consecutive breaths of nitrogen; steady state isocapnic hypoxia with step changes in end-tidal O2 concentration (range 5–8.5%) and maintained for 6–9 min at each level. Linear relationships were found between minute ventilation (\(\dot V\) I) and tidal volume (VT) in both types of hypoxia. However, a breakpoint emerged in the\(\dot V\) I-VT line of steady state hypoxia when VT and\(\dot V\) I reached 317% and 509% (mean values), respectively, of their baseline values. The slope of steady stateI-VT line below the breakpoint was 22.7 min−1 (weighted mean) which was not significantly different (P>0.1) from that of transient hypoxia (17.3 min−1). During steady state hypoxia both durations of inspiration and expiration were shorter than those during transient hypoxia in the same range of VT in four of these dogs. These differences in respiratory volume-timing relationship may be related to the central effect(s) of steady state hypoxia.
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Supported by USPHS NIH Research Grants HL-25089 and BRSG RR-05374
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Lee, LY., Morton, R.F. A comparison of breathing pattern between transient and steady state hypoxia in awake Dogs. Lung 162, 15–26 (1984). https://doi.org/10.1007/BF02715624
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DOI: https://doi.org/10.1007/BF02715624