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Effects of tannins from different sources on airway epithelial and platelet function

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Abstract

The uniqueness of tannin isolated from aqueous extracts of cotton bracts (CBE) on the electrophysiological and ion transport properties of the canine tracheal epithelium and on 5-hydroxytryptamine (5-HT) release from platelets was investigated. The effect of CBE from Deltapine 41 cotton picked before (green, containing high-concentration, high-molecular-weight tannin) and after (brown, containing low-concentration, low-molecular-weight tannin) senescence and Darjeeling tea extracts and tannin isolated from Darjeeling tea were compared to the effects of Acala SJ-2 CBE and Acala SJ-2 tannin. Green Deltapine 41 CBE was similar to Acala SJ-2 CBE in decreasing short-circuit current (Isc) and net chloride secretion and in producing a dose-response release of 5-HT from platelets. Both Green and Brown Deltapine 41 CBE altered the paracellular pathway, but were less potent than Acala SJ-2 CBE. Brown Deltapine 41 CBE stimulated chloride transport in the airway epithelium and did not produce 5-HT release from human platelets. Darjeeling tea and tea tannin increased Isc and net chloride secretion and caused 5-HT release from platelets only at high concentrations. These studies demonstrate that all tannins are not alike; they suggest that molecular weight and concentration may be important for tannin activity and that the tannin in cotton bracts extract may be unique to cotton in its effect on the airway epithelium and on platelets.

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References

  1. Bell AA, Stipanovic RD (1983) Biologically active compounds in cotton: an overview. In: Wakelyn PJ and Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 7. National Cotton Council, Memphis, pp 77–80

    Google Scholar 

  2. Bouhuys A (1976) Byssinosis: scheduled asthma in the textile industry. Lung 154:3–16

    PubMed  CAS  Google Scholar 

  3. Bruning JL, Kintz BL (1977) Computational handbook of statistics, 2nd ed. Scott, Foresman and Company, Glenview, IL, pp 113–116

    Google Scholar 

  4. Carpenado T, Bortignon C, Bruni A, Santi R (1969) Effect of quercetin on membrane linked activities. Biochem Pharmacol 18:1495–1500

    Article  Google Scholar 

  5. Castellan RM, Boehlecke BA, Petersen MR, Thedell TD, Merchant JA (1981) Pulmonary function and symptoms in herbal tea workers. Chest 79(4):815–855

    Google Scholar 

  6. Castellan RM, Olenchock SA, Kinsley KB, Hankinson JL (1987) Inhaled endotoxin and decreased spirometric values—an exposure-response relation for cotton dust. N Engl J Med 317:605–610

    Article  PubMed  CAS  Google Scholar 

  7. Chan BG (1985) From L-phenylalanine to condensed tannins: a brief review of tannin chemistry and biochemistry and a report of its distribution in cotton plant parts. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 9. National Cotton Council, Memphis, pp 49–52

    Google Scholar 

  8. Cloutier MM, Lesniak KM, Russell JA, Rohrbach MS (1984) Effect of cotton bracts extract on canine tracheal epithelium and shunt pathway. Am Rev Respir Dis 130:1087–1090

    PubMed  CAS  Google Scholar 

  9. Cloutier MM, Rohrbach MS (1986) Effects of endotoxin and tannin isolated from cotton bracts on the airway epithelium. Am Rev Respir Dis 134:1158–1162

    PubMed  CAS  Google Scholar 

  10. Cooke TF (1979) Chemical composition of cotton dust and its relation to byssinosis a review of the literature. Textile Res J 49:398–404

    CAS  Google Scholar 

  11. Edwards J (1981) Mechanism of disease induction. Chest 79:385

    Google Scholar 

  12. Edwards JH, AlZubaidy TS, Altikriti R, Bunny H (1984) Byssinosis inhalation challenge with polyphenol. Chest 85(2):215–217

    PubMed  CAS  Google Scholar 

  13. Edwards JH, Jones BM (1973) Pseudo-immune precipitation by the isolated byssinosis antigen. J Immunol 110:498

    PubMed  CAS  Google Scholar 

  14. Fawcett IW, Merchant JA, Simmonds SP, Pepys J (1978) The effect of sodium cromoglycate, beclomethasone diproprionate and salbutamol on the ventilatory response to cotton dust in mill workers. Br J Dis Chest 72:29–38

    Article  PubMed  CAS  Google Scholar 

  15. Hitchcock M (1974) In vitro histamine release from human lung as a model for the acute response to cotton dust. Ann NY Acad Sci 221:124–131

    Article  PubMed  CAS  Google Scholar 

  16. Kawamoto MM, Garabrant DH, Heed J, Balmes JR, Patzman J, Dimick DV, Simonowitz JA, Bernstein L (1987) Respiratory effects of cotton dust exposure in the cotton garnetting industry. Am J Ind Med 11:505–515

    Article  PubMed  CAS  Google Scholar 

  17. Kilburn KH, Lynn WS, Tres LL, McKenzie WN (1973) Leukocyte recruitment through airway walls by condensed vegetable tannins and quercetin. Lab Invest 28(1):55–59

    PubMed  CAS  Google Scholar 

  18. Lantz RC, Hinton DE, Burrell R (1984) The effect of inhaled bacterial lipopolysaccharide (LPS) on pulmonary endothelium. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 8. National Cotton Council, Memphis, pp 109–111

    Google Scholar 

  19. Lauque DE, Schroeder MA, Rohrbach MS (1988) Comparison of the acute pulmonary inflammatory response in inhaled cotton dust extracts and tannin. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 12. National Cotton Council, Memphis, pp 53–57

    Google Scholar 

  20. Marin MG, Davis B, Nadel JA (1977) Effect of histamine on electrical and ion transport properties of tracheal epithelium. J Appl Physiol 42:735–738

    PubMed  CAS  Google Scholar 

  21. McCormick JP, Ryan KA (1985) High performance liquid chromatographic analysis of cotton dusts, flax dusts and gossypium tannins. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 9. National Cotton Council, Memphis, pp 53–57

    Google Scholar 

  22. Noweir MH (1981) Studies on the etiology of byssinosis. Chest 79(4):62S-67S

    PubMed  CAS  Google Scholar 

  23. Orloff KG, Michaeli D (1976) Fibrin-induced release of platelet serotonin. Am J Physiol 231:334–344

    Google Scholar 

  24. Rohrbach MS, Kreofsky T, Chan BG (1986) Determinants of platelet agonist activity of condensed tannin. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 10. National Cotton Council, Memphis, pp 145–147

    Google Scholar 

  25. Rohrbach MS, Rolstad RA, Russell JA (1986) Tannin is the major agent present in cotton mill dust responsible for human platelet 5-hydroxytryptamine secretion and thromboxane formation. Lung 164:187–197

    Article  PubMed  CAS  Google Scholar 

  26. Rohrbach MS, Rolstad RA, Tracy PB, Russell JA (1984) Platelet 5-hydroxytryptamine release and aggregation promoted by cotton bracts tannin. J Lab Clin Med 103(1):152–160

    PubMed  CAS  Google Scholar 

  27. Russell JA, Gilberstadt ML, Rohrbach MS (1982) Constrictor effect of cotton bract extract on isolated canine airways. Am Rev Respir Dis 125:727–733

    PubMed  CAS  Google Scholar 

  28. Russell JA, Simons EJ, Kreofsky T, Rohrbach MS (1985) The action of endotoxin and flax dust extract on airway smooth muscle and human platelets. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 9. National Cotton Council, Memphis, pp 151–153

    Google Scholar 

  29. Rylander R (1984) Neutrophil invasion into airways after exposure to cotton dust with and without tannin. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 8. National Cotton Council, Memphis, pp 41–42

    Google Scholar 

  30. Rylander R, Beijer L (1984) Endotoxin and PAF-acether production by alveolar macrophages. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the Cotton Dust Research Conference No. 8. National Cotton Council, Memphis, pp 107–108

    Google Scholar 

  31. Schachter EN, Brown S, Zuskin E, Buck M, Kolack B, Bouhuys A (1981) Airway reactivity in cotton bract-induced bronchospasm. Am Rev Respir Dis 123:273–276

    PubMed  CAS  Google Scholar 

  32. Taylor G, Massoud AAE, Lucas F (1971) Studies on the aetiology of byssinosis. Br J Ind Med 28:143–151

    PubMed  CAS  Google Scholar 

  33. Tracy PB, Peterson JM, Nesheim ME, McDuffie FC, Mann KG (1979) Interaction of coagulation factor V and factor Va with platelets. J Biol Chem 254:10354

    PubMed  CAS  Google Scholar 

  34. Zuskin E, Skuric Z (1983) Respiratory function in tea workers. Br J Ind Med 41:88–93

    Google Scholar 

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Authors and Affiliations

  1. Thoracic Diseases Research Unit, Mayo Foundation, Rochester, Minnesota, USA

    Michael S. Rohrbach

  2. Department of Pediatrics, University of Connecticut Health Center, 263 Farmington Avenue, 06032, Farmington, CT, USA

    Michelle M. Cloutier

Authors
  1. Michelle M. Cloutier
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  2. Michael S. Rohrbach
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Cloutier, M.M., Rohrbach, M.S. Effects of tannins from different sources on airway epithelial and platelet function. Lung 167, 117–128 (1989). https://doi.org/10.1007/BF02714938

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