, Volume 165, Issue 1, pp 159–163 | Cite as

Immunogenetic factors as determinants of asbestosis

  • R. Bégin
  • H. Ménard
  • F. Décarie
  • A. St-Sauveur


To evaluate the possible role of immunogenetic factors as predisposing determinants of the development of asbestosis in exposed workers, we obtained 53 phenotypes of the human leucocyte antigen (HLA)-A, B, C, and DR antigens in 72 long-term workers of the mines and mills of Quebec and in a reference population of 150 residents. Among the asbestos workers, 32 did not have any abnormality and 40 had asbestosis. The 2 groups did not differ in term of age, exposure, or cigarette smoking habits. In agreement with previous reports, we found no significant change in frequency of the HLA-A, B, or C phenotypes. Furthermore, we did not find any significant change in the frequency of 10 phenotypes of the HLA-DR loci. We conclude that immunogenetic factors are not major predisposing determinants of asbestosis.

Key words

Asbestosis Immunology HLA antigens 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. Bégin
    • 1
  • H. Ménard
    • 1
  • F. Décarie
    • 2
  • A. St-Sauveur
    • 1
  1. 1.Centre Hospitalier UniversitaireUniversité de SherbrookeSherbrooke
  2. 2.Canadian Red Cross SocietyOttawaCanada

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