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Autonomic modulation of bronchoconstriction after pulmonary microembolism in guinea pigs

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Abstract

Respiratory resistance was measured using an oscillation technique in anaesthetised and paralysed guinea pigs before and after pulmonary micro-embolism induced with 0.5 ml/kg 10% W/V suspension of barium sulphate. There was no change in respiratory resistance in vagally intact animals but there was a 36% rise after priorβ-blockade with propranolol and a 30% increase following bilateral cervical vagotomy.β-sympathetic blockade did not potentiate the bronchoconstriction, caused by pulmonary microembolism, in vagotomised animals. These results suggest that microembolism is accompanied by an autonomic bronchodilator reflex which moderates its bronchoconstricting effect.

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Author notes

  1. T. P. Clay

    Present address: Department of Pharmacology, Roussel Laboratories Limited, Kingfisher Drive, Covingham, Swindon, Wilts., UK

Authors and Affiliations

  1. Departments of Radiology and Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, W12 OHS, London, UK

    T. P. Clay & J. M. B. Hughes

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  1. T. P. Clay
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  2. J. M. B. Hughes
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Clay, T.P., Hughes, J.M.B. Autonomic modulation of bronchoconstriction after pulmonary microembolism in guinea pigs. Lung 161, 275–285 (1983). https://doi.org/10.1007/BF02713873

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