Revista de Oncología

, Volume 6, Issue 5, pp 307–309 | Cite as

Angiosarcoma de bajo grado tras radioterapia en cáncer de mama

  • Belén Loboff de LeónEmail author
  • Jesús García-Donas Jiménez
  • Miguel Martín Jiménez
  • Rosario Carrillo Gijón
  • Eduardo Díaz Rubio
Notas Clínicas

Palabras clave

cáncer de mama angiosarcoma sarcoma postradiación 

Low-grade angiosarcoma following radiotherapy in breast cancer


Angiosarcoma of the skin (AS) is a rare complication of radiotherapy. It is characterised by its aggressive clinical progression and is distinct from other forms of angiosarcoma in that it does not always present with chronic lymphedema. A survey of the literature reveals that these lesions are difficult to diagnose because of their rarity and variable appearance, and because they can mimic radiation-induced changes in the skin. The majority of articles describe high-grade lesions. We report, here, a case of low-grade angiosarcoma following radical mastectomy, axillar node dissection and radiotherapy for infiltrating ductal carcinoma. Prompt diagnosis is very dependent on a high degree of clinical awareness. A biopsy should be considered in patients who present new skin lesions following radiotherapy for breast cancer.

Key words

breast cancer angiosarcoma post-radiotherapy 


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  1. 1.
    Cafiero F, Gipponi M, Peressini A, et al. Radiation-associated angiosarcoma: diagnostic and therapeutic implications—two case reports and review of the literature. Am Cancer Society 1996;77(12):2496–502.Google Scholar
  2. 2.
    Del Mastro L, Garrone O, Guenzi M, et al. Angiosarcoma of the residual breast after conservative surgery and radiotherapy for primary carcinoma. Ann Oncol 1994; 5(2):163–5.CrossRefGoogle Scholar
  3. 3.
    Davies JD, Mees GJG, Mera SL. Angiosarcoma in irradiated post-mastectomy chest wall. Histopathology 1987;7:947–56.CrossRefGoogle Scholar
  4. 4.
    Marchal C, Weber B, De Lafontan B, et al. Nine breast angiosarcoma after conservative treatment for breast carcinoma: a survey from French comprehension cancer center. Int J Radiation Oncology Biol Phys 1999;44(1):113–9.CrossRefGoogle Scholar
  5. 5.
    Cahan WG, Woodward HO, Higinbotham NL, et al. Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1998;1:3–29.CrossRefGoogle Scholar
  6. 6.
    Polgar C, Orosz Z, Szerdahelyi A, et al. Postradiation angiosarcoma of the chest wall and breast: issues of radiogenic origin, diagnosis and treatment in two cases. Oncology 2001;60:31–4.CrossRefGoogle Scholar
  7. 7.
    Sener SF, Milos S, Feldman JL, et al. The spectrum of vascular lesions in the mamary skin, including angiosarcoma after breast conservation treatment for breast cancer. J Am Coll Surg 2001;193(1):22–8.CrossRefGoogle Scholar
  8. 8.
    Feigenberg SJ, Price N, Reith JD, et al. Angiosarcoma after breast-conserving therapy: experience with hyperfractionated radiotherapy. Int J Radiation Oncology Biol Phys 2002;52(3):620–6.CrossRefGoogle Scholar
  9. 9.
    Williams EV, Banerjee D, Dallimore N, Monypenny IJ. Angiosarcoma of the breast following radiation therapy. Eur J Sur Oncol 1999;25:221–7.CrossRefGoogle Scholar

Copyright information

© FESEO 2004

Authors and Affiliations

  • Belén Loboff de León
    • 2
    Email author
  • Jesús García-Donas Jiménez
    • 2
  • Miguel Martín Jiménez
    • 2
  • Rosario Carrillo Gijón
    • 1
  • Eduardo Díaz Rubio
    • 2
  1. 1.Servicio de Anatomía PatológicaHospital Ramón y CajalMadridEspaña
  2. 2.Servicio de Oncología MédicaHospital Clínico San CarlosMadridEspaña

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