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Radioterapia preoperatoria en el melanoma de coroides con afectación extraescleral

Pre-enucleation radiotherapy in uveal melanoma with extrascleral extension

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Resumen

El melanoma de coroides con afectación extraescleral representa aproximadamente el 4%–10% de los melanomas uveales. Constituye un reconocido factor pronóstico adverso, tanto para la recurrencia local como para la supervivencia global. La enu-cleación asociada a la resección quirúrgica de la extensión extraescleral es el tratamiento de elección, aunque los pobres resultados obtenidos con el tratamiento quirúrgico aislado han animado a la búsqueda de tratamientos complementarios a la cirugía. Se presenta la experiencia del Hospital Universitario de Valladolid en el tratamiento de 6 casos de melanoma con afectación extraescleral tratados con radioterapia preenucleación, analizando los resultados obtenidos, los cambios radioinducidos y la similitud con los casos publicados en la literatura.

Abstract

Extrascleral extension is present in 4%–10% of uveal melanomas. It's a relevant risk factor for local recur-rence and survival. Enucleation with surgical resection of the extrascleral extension is the treatment of choice. The poor results obtained with isolated surgery, have encouraged to search adjunctive treatments. We present the experience of the University Hospital of Valladolid in the treatment of 6 cases of uveal melanoma with extrascleral extension treated with pre-enucleation radiotherapy. We analize the results, the histopathologic findings induced in the enucleated eyes and the cases published in the literature.

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Authors and Affiliations

  1. Servicio de Oftalmología, Hospital Universitario. IOBA, Valladolid, Spain

    M. Antonia Saornil Álvarez & Gonzalo Blanco Meteos

  2. Servicio de Oncología, Hospital Universitario, C./Ramón y Cajal, s/n, 47011, Valladolid, Spain

    Carmen González San Segundo & Francisco López-Lara Martin

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  1. Carmen González San Segundo
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  2. M. Antonia Saornil Álvarez
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  3. Gonzalo Blanco Meteos
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  4. Juan A. Santos Miranda
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  5. Francisco López-Lara Martin
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Correspondence to Carmen González San Segundo.

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Segundo, C.G.S., Antonia Saornil Álvarez, M., Meteos, G.B. et al. Radioterapia preoperatoria en el melanoma de coroides con afectación extraescleral. Rev Oncol 4, 28–32 (2002). https://doi.org/10.1007/BF02711636

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  • DOI: https://doi.org/10.1007/BF02711636

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