Presentación de masa mediastínica gigante en un varón de 15 años con síndrome de Klinefelter
- 31 Downloads
Palabras clavemasa mediastínica tumores de células germinales teratoma Klinefelter adolescentes
Giant mediastinal mass in a 15-year-old boy with Klinefelter syndrome
Intrathoracic masses are infrequent in children. We report the case of a 15 year old boy suffering Klinefelter syndrome who was referred to our hospital whith a casual radiographic finding of an intrathoracic mass, which occupied over 2/3 of the left hemithorax. The increased risk of neoplasm development in Klinefelter syndrome, mainly breast cancer and primary mediastinal germ cell tumors, especially between 15 and 30 years of age is wellknown. The existence of immature elements in the pathology study of the teratoma allows the classification of mature and immature tumors, their aggressiveness, treatment and prognosis depending on this. In our case, we found a solid mass of 10×15×17 cm located in the anterior mediastinum with areas of necrosis and small calcifications which was reported as an immature teratoma in the pathology report. Due to the large tumor size and its relationship to near structures, chemotherapy treatment was initiated in a failed attempt to reduce the mass, followed by surgical resection and 2 more chemotherapy cycles. Plasma levels of alfa-feto-protein and beta-HCG were highly increased at diagnosis but they were notably reduced after surgery and normalized at the end of the treatment and during the follow up.
Key wordsmediastinal mass germ cell tumors teratoma Klinefelter adolescents
Unable to display preview. Download preview PDF.
- 7.Martínez M, Pérez F, Pereira A. Tumores germinales gonadales en niños. Experiencia en el S. A. Hospital de niños JM De Los Ríos 1995–1998. Revista Venezolana de Oncología. Disponible en: http://www.infomedonline. com.ve/oncologia/onc122art1.pdfGoogle Scholar