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Locoregional recurrence and metastasis in the long-term follow-up of postmastectomy breast cancer patients with T1–T2 tumours and one to three positive lymph nodes

Recidiva locorregional y metástasis en el seguimiento a largo plazo de pacientes con cáncer de mama con mastectomía con tumores T1–T2 y uno a tres ganglios positivos

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Abstract

Introduction

In this work we want to know the long-term rates of locoregional recurrence and distant metastasis in a population of breast cancer patients with pT1–pT2 tumours and one to three positive lymph nodes who were treated with mastectomy and axillary lymphadenectomy, and to study the relationship of certain clinical and histopathological parameters to their development.

Material and methods

Ninety patients diagnosed with a breast tumour of less than 5 cm and one to three affected lymph node, and undergoing a modified radical mastectomy with axillary lymphadenectomy, were studied. The mean overall follow-up was 132 months, and the minimum follow-up for the living patients was 10 years. Locoregional recurrence and metastasis development rates were studied and clinical and pathological parameters were evaluated.

Results

We found locoregional recurrence in 22.5% of the patients, and systemic metastases in 30.3%. In the study of locoregional recurrences significant differences were found for tumour size (T2) (p=0.001) and metastasis were more frequent with extracapsular lymph node extension (p=0.02) and non-administration of chemotherapy (0.019).

Conclusions

The parameter related to the development of locoregional recurrence was tumour size (stage T2) and those related to the development of metastasis were extracapsular lymph node extension and non-administration of chemotherapy.

Resumen

|Introducción

En este trabajo pretendemos conocer la tasa de recidiva locorregional y metástasis a distancia en el seguimiento a largo plazo de las pacientes intervenidas por cáncer de mama con tumores pT1–pT2 y uno a tres ganglios positivos que fueron tratadas con mastectomía y linfadenectomía axilar, así como estudiar la posible relación de determinados parámetros clínicos e histopatológicos con su desarrollo.

|Material y métodos

Se han estudiado 90 pacientes diagnosticadas de cáncer de mama con un tumor menor de 5 cm y uno a tres ganglios afectados, y que fueron intervenidas mediante mastectomía radical modificada con linfadenectomía. El seguimiento medio fue de 132 meses, con un seguimiento mínimo para las pacientes vivas de 10 años. Se calcularon las tasas de recurrencia locorregional y metástasis y se evaluaron parámetros clínicos e histopatológicos.

|Resultados

Se encontró recurrencia locorregional en le 22,5% de los casos, y metástasis en el 30,3%. Se encontraron diferencias significativas para la aparición de recurrencia en el tamaño tumoral (T2) (p=0,001) y las metástasis fueron más frecuentes en casos con afectación ganglionar extracapsular (p=0,02) y la no administración de quimioterapia (p=0,019).

|Conclusiones

El parámetro que se relaciona con el desarrollo de recurrencias locorregionales fue el tamaño tumoral (estadio T2) y los que se relacionaron con el desarrollo de metástasis fueron la extensión extracapsular ganglionar y la no administración de quimioterapia.

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Authors and Affiliations

  1. Department of General Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain

    Antonio Piñero Madrona & Julián Illana Moreno

  2. Department of Radiotherapeutic Oncology, Virgen de la Arrixaca University Hospital, Murcia, Spain

    Juan Salinas Ramos & Manuel de las Heras González

  3. Department of Pathology, Virgen de la Arrixaca University Hospital, Murcia, Spain

    Joaquín Sola Pérez

  4. Department of Statistics, School of Medicine, Murcia, Spain

    Manuel Canteras Jordana & Pascual Parrilla Paricio

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  1. Antonio Piñero Madrona
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  2. Juan Salinas Ramos
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Correspondence to Antonio Piñero Madrona.

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Madrona, A.P., Ramos, J.S., Moreno, J.I. et al. Locoregional recurrence and metastasis in the long-term follow-up of postmastectomy breast cancer patients with T1–T2 tumours and one to three positive lymph nodes. Rev Oncol 6, 341–346 (2004). https://doi.org/10.1007/BF02710063

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