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Synthesis and characterization of mixed ligand complexes of Zn(II) and Co(II) with amino acids: Relevance to zinc binding sites in zinc fingers

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Abstract

Mixed ligand complexes of Zn(II) and Co(II) with cysteine, histidine, cysteinemethylester, and histidinemethylester have been synthesized and characterized by elemental analysis, conductivity, magnetic susceptibility measurements, and infrared,1H NMR, TGA and FAB mass spectra. In these complexes, histidine, and histidinemethylester act as bidentate ligands involving amino and imidazole nitrogens in metal coordination. Similarly, cysteine, and cysteinemethylester also act as bidentate ligands coordinating through thiol sulphur and amino nitrogen. Tetrahedral geometry has been proposed for Zn(II) and Co(II) complexes based on experimental evidence.

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References

  1. Bertini I, Luchinat C, Maret W and Zeppezauer M (eds) 1986Zinc enzymes (Boston: Birkhaused)

    Google Scholar 

  2. Christianson D W 1991Adv. Protein Chem. 42 281

    Article  CAS  Google Scholar 

  3. Vallee B L and Auld D S 1993Acc. Chem. Res. 26 5433

    Article  Google Scholar 

  4. Burger K (ed.) 1990Biocoordination chemistry: Coordination equilibria in biologically active systems (New York: Ellis Horwood)

    Google Scholar 

  5. Rombach M, Gelinsky M and Vahrenkamp H 2002Inorg. Chim. Acta 334 25

    Article  CAS  Google Scholar 

  6. Ranganathan S, Jayaraman N and Roy R 1992Tetrahedron 48 931

    Article  CAS  Google Scholar 

  7. Nagaoka M and Sugiura Y 2000J. Inorg. Biochem. 82 57

    Article  CAS  Google Scholar 

  8. Reddy P R, Mohan S M and Rao K S 2004Indian J. Chem. A43 2329

    Google Scholar 

  9. Ranganathan S, Jayaraman N and Chatterji D 1997Biopolymers 41 407

    Article  CAS  Google Scholar 

  10. Parkin G 2004Chem. Rev. 104 699

    Article  CAS  Google Scholar 

  11. Gelinsky M and Vahrenkamp H 2002Eur. J. Inorg. Chem. 2458

  12. Boerzel H, Koeckert M, Bu W, Spingler B and Lippard S J 2003Inorg. Chem. 42 1604

    Article  CAS  Google Scholar 

  13. Spiro T (ed.) 1983Zinc enzymes (New York: Wiley)

    Google Scholar 

  14. Sigel H (ed.) 1983Metal ions in biological systems: Zinc and its role in biology and nutrition (New York: Marcel Dekker) vol. 15

    Google Scholar 

  15. Harrison P (ed.) 1985Metalloproteins, metal proteins with non-redox roles (Weinheim: VCH) part 2

    Google Scholar 

  16. Lin Q, Barbas C F and Schultz P G 2003J. Am. Chem. Soc. 125 612

    Article  CAS  Google Scholar 

  17. Pauletich N P and Pabo C O 1991Science 252 809

    Article  Google Scholar 

  18. Lee M S, Gippert G P, Soman K V, Case D A and Wright P E 1989Science 245 635

    Article  CAS  Google Scholar 

  19. Williams R J P 1987Polyhedron 6 61

    Article  CAS  Google Scholar 

  20. Berg J 1986Science 232 485

    Article  CAS  Google Scholar 

  21. Johnston M 1987Nature (London) 328 353

    Article  CAS  Google Scholar 

  22. Miller J, Malachaln A D and Klug A 1985EMBO J. 4 1609

    CAS  Google Scholar 

  23. Klug A and Rhodes R 1987Trends Biochem Sci. 12 464

    Article  CAS  Google Scholar 

  24. Fairall L, Rhodes D and Klug A 1986J. Mol. Biol. 192 577

    Article  CAS  Google Scholar 

  25. Dikan G P, Fairall L and Klug A 1986Nature (London) 324 698

    Article  Google Scholar 

  26. Brown R S, Sander C and Argos P 1985FEBS Lett. 186 271

    Article  CAS  Google Scholar 

  27. Brown R S and Argos P 1986Nature (London) 324 215

    Article  CAS  Google Scholar 

  28. Wingender E and Seifart K H 1987Angew. Chem., Int. Ed. Engl. 26 218

    Article  Google Scholar 

  29. Chang S, Karambelkar V V, Sommer R D, Rheingold A L and Goldberg D P 2002Inorg. Chem. 41 239

    Article  CAS  Google Scholar 

  30. Reddy P R, Reddy A M and Radhika M 1998Indian J. Chem. A37 775

    Google Scholar 

  31. Figgis B N and Lewis J 1967Modern coordination chemistry (eds) J Lewis and R C Wilkinson (New York: Wiley-Inter-Science) p. 403

    Google Scholar 

  32. Geary W J 1971J. Coord. Chem. Rev. 7 81

    Article  CAS  Google Scholar 

  33. Nokamoto K 1970Infrared spectra of inorganic and coordination compounds (New York: Wiley Inter-Science)

    Google Scholar 

  34. Bellamy L J 1975The infrared spectra of complex molecules, 3rd edn (London: Chapman and Hall)

    Google Scholar 

  35. Amparo C, Virtudes M, Eiles M and Carles M 1992J. Inorg. Biochem. 48 135

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, 500 007, Hyderabad, India

    P. Rabindra Reddy, M. Radhika & P. Manjula

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  1. P. Rabindra Reddy
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  2. M. Radhika
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  3. P. Manjula
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Correspondence to P. Rabindra Reddy.

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Reddy, P.R., Radhika, M. & Manjula, P. Synthesis and characterization of mixed ligand complexes of Zn(II) and Co(II) with amino acids: Relevance to zinc binding sites in zinc fingers. J Chem Sci 117, 239–246 (2005). https://doi.org/10.1007/BF02709293

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  • DOI: https://doi.org/10.1007/BF02709293

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