Skip to main content
Log in

Non-redundant tumour suppressor functions of transforming growth factor beta in breast cancer

  • Commentary
  • Published:
Journal of Biosciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Boivin G P, Molina J R, Ormsby I, Stemmermann G and Doetschman T 1996 Gastric lesions in transforming growth factor beta-1 heterozygous mice;Lab. Invest. 74 513–518

    Google Scholar 

  • Ee Y S, Lai L C, Reimann K and Lim P K 1999 Effect of transforming growth factor-beta 1 on oestrogen metabolism in MCF-7 and MDA-MB-231 breast cancer cell lines;Oncol. Rep. 6 843–846

    PubMed  CAS  Google Scholar 

  • Engle S J, Hoying J B, Boivin G P, Ormsby I, Gartside P S and Doetschman T 1999 Transforming growth factor beta 1 suppresses nonmetastatic colon cancer at an early stage of tumourigenesis;Cancer Res. 59 3379–3386

    PubMed  CAS  Google Scholar 

  • Erbas H and Lai L C 2000 Effect of transforming growth factor beta 2 on oestrogen metabolism in the MCF-7 breast cancer cell line;J. Clin. Pathol. 53 322–324

    Article  PubMed  CAS  Google Scholar 

  • Erbas H, Lennard T W and Lai L C 1999 Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid;Anticancer Res. 19 3077–3082

    PubMed  CAS  Google Scholar 

  • Joseph H, Gorska A E, Sohn P, Moses H L and Serra R 1999 Over expression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching;Mol. Biol. Cell 10 1221–1234

    PubMed  CAS  Google Scholar 

  • Massague J 1998 TGF-beta signal transduction;Annu. Rev. Biochem. 67 753–791

    Article  PubMed  CAS  Google Scholar 

  • Nguyen A V and Pollard J W 2000 Transforming growth factor beta 3 induces cell death during the first stage of mammary gland involution;Development 127 3107–3118

    PubMed  CAS  Google Scholar 

  • O’Connor-McCourt M D and Wakefield L M 1987 Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin;J. Biol. Chem. 262 14090–14099

    PubMed  CAS  Google Scholar 

  • Pelton R W, Saxena B, Jones M, Moses H L and Gold L I 1991 Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development;J. Cell Biol. 115 1091–1105

    Article  PubMed  CAS  Google Scholar 

  • Proetzel G, Pawlowski S A, Wiles M V, Yin M, Boivin G P, Howles P N, Ding J, Ferguson M W and Doetschman T 1995 Transforming growth factor-beta 3 is required for secondary palate fusion;Nature Genet. 11 409–414

    Article  PubMed  CAS  Google Scholar 

  • Roberts A B and Sporn M B 1990 The transforming growth factorbetas; inPeptide growth factors and their receptors — Handbook of experimental pathology (eds) M B Sporn and A B Roberts (Heidelberg: Springer-Verlag) pp 419–472

    Google Scholar 

  • Robinson S D, Silberstein G B, Roberts A B, Flanders K C and Daniel C W 1991 Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development;Development 113 867–878

    PubMed  CAS  Google Scholar 

  • Sanford L P, Ormsby I, Gittenberger-de Groot A C, Sariola H, Friedman R, Boivin G P, Cardell E L and Doetschman T 1997 TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes;Development 124 2659–2670

    PubMed  CAS  Google Scholar 

  • Shull M M, Ormsby I, Kier A B, Pawlowski S, Diebold R J, Yin M, Allen R, Sidman C, Proetzel G, Calvin D and Doetschman T 1992 Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease;Nature (London) 359 693–699

    Article  CAS  Google Scholar 

  • Torres R M and Kühn R 1997Laboratory protocols for conditional gene targeting (New York: Oxford University Press) pp 11–13

    Google Scholar 

  • Wakefield L M, Letterio J J, Chen T, Danielpour D, Allison R S, Pai L H, Denicoff A M, Noone M H, Cowan K H and O’Shaughnessy J A 1995 Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer;Clin. Cancer. Res. 1 129–136

    PubMed  CAS  Google Scholar 

  • Walker R A 2000 Transforming growth factor beta and its receptors: their role in breast cancer;Histopathology 36 178–180

    Article  PubMed  CAS  Google Scholar 

  • Zhu Y, Richardson J A, Parada L F and Graff J M 1998 Smad3 mutant mice develop Metastatic colorectal cancer;Cell 94 703–714

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Azhar, M. Non-redundant tumour suppressor functions of transforming growth factor beta in breast cancer. J Biosci 26, 9–12 (2001). https://doi.org/10.1007/BF02708975

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02708975

Keywords

Navigation