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References
Haldar K, Ferguson M A J and Cross GAM 1985 Acylation of aPlasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol;J. Biol. Chem. 260 4969–4974
Heath R J and Rock C O 2000 A triclosan-resistant bacterial enzyme;Nature (London) 406 145–146
Heath R J, Rubin J R, Holland D R, Zhang E, Snow M E and Rock C O 1999 Mechanism of Triclosan inhibition of bacterial fatty acid synthesis;J. Biol. Chem. 274 11110–11114
Heath R J, Yu Y-T, Shapiro M A, Olson E and Rock C O 1998 Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis;J. Biol. Chem. 273 30316–30320
Holz G G Jr 1977 Lipids and the malarial parasite;Bull. W.H.O. 55 237–248
Jomaa H., Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Türbachova I, Eberl M, Zeidler J, Lichtenthaler H K, Soldati D and Beck E 1999 Inhibitors of nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs;Science 285 1573–1576
Matesanz F, Duran-Chica I. and Alcina A 1999 The cloning and expression of pfacs1, aPlasmodium falciparum fatty acid coenzyme A synthetase-1 targeted to the host erythrocyte cytoplasm;J. Mol. Biol. 291 59–70
McConkey G A, Rogers J M and McCutchan T F 1977 Inhibition ofPlasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton;J. Biol. Chem. 272 2046–2049
McFadden, G I. and Roos, D S 1999 Apicomplexan plastids as drug targets;Trends Microbiol. 7 328–333
McMurray L M, Oethinger M and Levy S B 1998 Triclosan targets lipid synthesis;Nature (London) 394 531–532
Smith S 1994 The animal fatty acid synthase: one gene, one polypeptide, seven enzymes;FASEB J. 8 1248–1259
Surolia N and Surolia A 2001 Triclosan offers protection against blood stages of malaria by inhibiting enoyl ACP-reductase ofPlasmodum falciparum;Nature Med. 7 167–173
Waller R F, Keeling P J, Donald R G K, Striepen B, Handman E, Lang-Unnasch N, Cowman A F, Besra G S, Roos D S and McFadden G I 1998 Nuclear-encoded proteins target to the plastid inToxoplasma gondii andPlasmodium falciparum;Proc. Natl. Acad. Sci. USA 95 12352–12357
World Health Organization 1997 World malaria situation in 1994;Weekly Epidemiol. Rec. 72 269–274
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Bhat, G.P., Surolia, N. Triclosan and fatty acid synthesis inPlasmodium falciparum: New weapon for an old enemy. J Biosci 26, 1–3 (2001). https://doi.org/10.1007/BF02708972
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DOI: https://doi.org/10.1007/BF02708972