Abstract
To design a supercritical fluid extraction process for the separation of bioactive substances from natural products, a quantitative knowledge of phase equilibria between target biosolutes and solvent is necessary. How-ever, mostly no such information is available in literature to date. Thus in the present study, illustratively the solubility of bioactive coumarin and its various derivatives (i.e., hydroxy-, methyl-, and methoxy-derivatives) in supercritical CO2 were measured at 308.15–328.15 K and 10–30 MPa. Also, the pure physical properties such as normal boiling point, critical constants, acentric factor, molar volume and standard vapor pressure for coumarin and its derivatives were estimated. By these estimated information, the measured solubilities were quantitatively correlated by an approximate lattice equation of state proposed recently by the present authors.
Similar content being viewed by others
References
Bevan, C. D. and Marshall, P. S., “The Use of Supercritical Fluids in the Isolation of Natural Products”,Nat. Prod. Rep.,11, 451 (1994).
Choi, Y. H., Kim, J., Noh, M. J., Park, E. M. and Yoo, K. P., “Extraction of Epicuticular Wax and Nonacosan-10-ol fromEphedra herb Utilizing Supercritical Carbon Dioxide”,KJChE,13(2), 216 (1996).
Joo, S. J., Choi, Y. H., Kim, J., Noh, M. J., Park, E. M. and Yoo, K. P., “Supercritical Carbon Dioxide Extraction of Pharmaceutical Agents from Plant Materials in Korea”, Proc. 3rd Int. Symp. Supercrit. Fluids, Strasbourg, France, 2, 407 (1994).
King, M. B. and Bott, T. R., eds., “Extraction of Natural Products Using Near-Critical Solvents”, Chapman & Hall, London, 1993.
Lee, C. S. and Yoo, K.-P., “Lattice-hole Based Equations of State and Their Applications to Complex Fluids”, Proc. Int. Symp. on Molec. Thermo. & Molec. Simul., Hosei Univ., Tokyo, Japan,109, 53 (1997).
Liu, B., Lockwood, B. and Gifford, L. A., “Supercritical Fluid Extraction of Diosgenin from Tubers ofDioscorea nipponica”,J. Chromatogr.,690, 250 (1995).
Lyman, W. J., Reehl, W. F. and Rosenblattt, D. H., “Handbook of Chemical Property Estimation Methods”, ACS Press, Washington, DC, Ch. 12 (1990).
Ma, X., Yu, X., Zhang, Z. and Mao, J., “Analytical Supercritical Fluid Extraction of Chinese Herbal Medicines”,Chromatographia,32, 40 (1991).
Modey, W. K., Mulholland, D. A. and Raynor, M. W., “Analytical Supercritical Fluid Extraction of Natural Products”,Phytochem. Anal,4, 1 (1996).
Noh, M. J., Choi, E. S., Yoo, K.-P., Choi, Y. H., Yeo, H., Lee, J., Park, E. J., Kim, J. W., Park, H. K. and Kim, K. H., “Selective Extraction of Bioactive Substances from Natural Medicinal Resources Utilizing Supercritical Fluid Technology”,Korean Chem. Ind. & Tech.,15, 16 (1997).
Noh, M. J., Choi, E. S., Kim, S. H., Yoo, K.-P., Choi, Y. H., Chin, Y. W. and Kim, J. W., “Supercritical Fluid Extraction and Bioassay Identification of Prodrug Substances from Natural Resources”,KJChE,14(2), 109 (1997).
Reid, R. C, Prausnitz, J. M. and Poling, B. E., “The Properties of Gases and Liquids”, 4th ed., McGraw-Hill Book Co., Ch. 3 & 7 (1987).
Rizvi, S. S. H., ed., “Supercritical Fluid Processing of Food and Biomaterials”, Blackie Academic and Professional Co., London, 1994.
Smith, R. M. and Burford, M. D., “Supercritical Fluid Extraction and Gas Chromatographic Determination of the Sesquiterpene Lactone Parthenolide in the Medicinal Herb Feverfew (Tanacetum parthenium)”,J. Chromatogr.,627, 255 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoo, KP., Shin, H.Y., Noh, M.J. et al. Measurement and modeling solubility of bioactive coumarin and its derivatives in supercritical carbon dioxide. Korean J. Chem. Eng. 14, 341–346 (1997). https://doi.org/10.1007/BF02707049
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02707049