Abstract
Self-transformable and blood compatible devices of sulfonated poly(ethylene glycol) acrylate diblock copolymer (PEG-SO3A/OA) with hydrophilic and hydrophobic block entrapped to polysulfone membrane surface were investigated in terms of the degree of hydrophilicity. The asymmetric membrane was formed by phase inversion process, and the induced hydrophilicity by reorientation of diblock copolymer at interface was verified with contact angle measurement, electron spectroscopy for chemical analysis (ESCA) depth profiling with ion sputtering and platelet adhesion test. Molecular dynamics (MD) simulations for the interface of hydration layer were also performed with various hydrophilic copolymer densities to gain optimum interfacial structure in information. The dependency of water clustering behavior around diblock copolymers as a hydrophilicity parameter was described in terms of atom-atom radial distribution function (RDF). The results showed that the diblock copolymer entrapped surfaces demonstrated less platelet adhesion than control or copolymers having no hydrophobic blocks. In addition, oxygen composition significantly began to decrease deeper into the membrane, indicating the reorientation of diblock chains. Copolymer entrapped surfaces significantly induced the degree of water clustering, and the resulting equilibrium rearrangement of interfacial structures was distinctly dependent upon the density of copolymer. Taken together, the results show that the novel concept ofin situ self-transformable surface modification strategy was successfully developed for biocompatible ultrathin biomedical membrane device.
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References
Antonsen, K. P. and Hoffman, A. S., “Water Structure of PEG Solutions by Differential Scanning Calorimetry Measurements” In Poly(ethylene glycol) Chemistry, Harris, J. M. (ed.), Plenum Press, New York, 15 (1992).
Bergstrom, K., Osterberg, E., Holmberg, K., Hoffman, A. S., Schuman, T. P., Kozlowski, A. and Harris, J. M., “Effect of Branching and Molecular Weight of Surface-Bound Poly(ethylene oxide) on Protein Rejection,”J. Biomater. Sci. Polymer Edn.,6, 123 (1994).
Bopp, P. A. and Heinzinger, K., “MD Studies of Electrolyte Solution/ Liquid Mercury Interfaces,”J. Electrocuted. Chem.,450, 165 (1998).
Chang, J. and Kim, H., “Molecular Dynamic Simulation and Equation of State of Lennard-Jones Chain Fluids,”Korean J. Chem. Eng.,15, 544 (1998).
Chun, M. S. and Baig, C., “Molecular Simulation Study on the Colloidal Suspension within Dilute Fibrous Media: The Effect of Particle Concentration on Partitioning”Korean J. Chem. Eng.,18, 816 (2001).
Cosgrove, T., Heath, T. G., Ryan, K. and van Lent, B., “The Conformation of Adsorbed Poly(ethylene oxide) at the Polystyrene/Water Interface,”Polymer Comm.,28, 64 (1987).
Gombotz, W. R., Guanghui, W., Horbett, T A. and Hoffman, A. S., “Protein Adsorption to Poly(ethylene oxide) Surfaces,”J. Biomed. Mater. Res.,25,1547(1991).
Gristina, A. G., Hobgood, C. D., Webb, L. X. and Myrvik, Q. M., “Adhesive Colonization of Biomaterials and Antibiotic Resistances,”Biomaterials,8, 423 (1987).
Hancock, L. F., Fagan, S. M. and Ziolo, M. S., “Hydrophilic, Semipermeable Membranes Fabricated with Poly(ethylene oxide)-Polysulfone Block Copolymer,”Biomaterials,21, 725 (2000).
Jeon, G S., Han, M. H. and Seo, G., “Effect of ZnO Contents at the Surface of Brass-Plated Steel Cord on the Adhesion Property to Rubber Compound,”Korean J. Chem. Eng.,16, 248 (1999).
Kim, B. K., Ban, Y B. and Kim, J. D., “Experimental Studies on Phase Equilibria of Peg-Water-Dextran/Ammonium Sulfate Systems and Partitioning of Albumin into Two Water-Continuous Phases,”Korean J. Chem. Eng.,9, 219 (1992).
Kim, C. K., Kim, S. S., Kim, D. W, Lim, J. C. and Kim, J. J., “Removal of Aromatic Compounds in the Aqueous Solution via Micellar Enhanced Ultrafiltration: Part 1. Behavior of Nonionic Surfactants,”J. Membrane Sci.,147,13 (1998).
Kim, H. J., Mohammadi, T, Kumar, A. and Fouda, A. E., “Asymmetric Membranes by a Two-Stage Gelation Technique for Gas Separation: Formation and Characterization,”J. Membrane Sci.,161, 229 (1999).
Kim, Y. J., Lee, Y M., Lee, H. M. and Park, O. O., “Processabilities & Mechanical Properties of the Biodegradable LDPE/Modified Starch Blends,”Korean J. Chem. Eng.,11, 172 (1994).
Ko, Y G., Kim, Y. H., Park, K. D., Lee, H. I, Lee, W. K., Park, H. D., Kim, S. H., Lee, G. S. and Ahn, D. J., “Immobilization of Polyethylene glycol) or Its Sulfonate onto Polymer Surfaces by Ozone Oxidation,”Biomaterials,22, 2115 (2001).
Lee, H. J., Park, K. D., Park, H. D., Lee, W. K., Han, D. K., Kim, S. H. and Kim, Y H., “Platelet and Bacterial Repellence on Sulfonated Poly(ethylene glycol)-Acrylate Copolymer Surfaces,”Colloids and Surf. B: Biointerfaces,18, 355 (2000).
Lee, W. J., Kim, D. S. and Kim, J. H., “Preparation and Gas Separation Properties of Asymmetric Polysulfone Membranes by a Dual Bath Method,”Korean J. Chem. Eng.,17,143 (2000).
Llanos, G. R. and Sefton, M. V, “Does Polyethylene Oxide Possess a Low Thrombogenicity?”J. Biomater. Sci. Polymer Edn.,4, 381 (1993).
Milner, S. T, “Polymer Brush,”Science,251, 905 (1991).
Murat, M. and Grest, G S., “Structure of Grafted Polymer Brush: A Molecular Dynamics Simulation,”Macromolecules,22,4054 (1989).
Neelov, I., Niemela, S. and Sundholm, F A, “Computer Simulation of the Molecular Properties of Amorphous Poly(vinyl chloride), PVC,”J. Non-Crystalline Solids,235, 340 (1998).
Park, J. K. and Seo, J. I., “Characteristics of Phenylalanine Imprinted Membrane Prepared by the Wet Phase Inversion Method,”Korean J. Chem. Eng.,19, 940 (2002).
Park, K., Park, J., Song, H., Shin, H., Park, J. and Ahn, J. S., “Biological Reprocessing of Mixed Office Waste (MOW) Using Modified Cellulase by Production of Functional Copolymef,”Korean J. Chem. Eng.,19, 285 (2002).
Robert, L. O. and Joseph, E. J., “Thin Films and Interfaces in Microelectronics: Composition and Chemistry as Function of Depth,”Progress in Surface Science,69, 125 (2002).
Soper, A. K. and Philips, M. G., “A New Determination of the Structure of Water at 25 °C,”Chem. Phys.,107,47 (1985).
Su, Y L. and Liu, H. Z., “Temperature-Dependent Solubilization of PEO-PPO-PEO Block Copolymers and Their Application for Extraction Trace Organics from Aqueous Solutions,”Korean J. Chem. Eng.,20, 343 (2003).
Tadokoro, H., Chatani, Y., Yoshihara, T, Tahara, S. and Murahashi, S., “Structural Studies on Polyethers, [-(CH2)m-O-]2. II. Molecular Structure of Polyethylene Oxide,”Makromol. Chem.,73, 109 (1964).
Watanabe, J., Ooya, T, Nitta, K. H., Park, K. D., Kim, Y H. and Yui, N., “Fibroblast Adhesion and Proliferation on Poly(ethylene glycol) Hydrogels Crosslinked by Hydrolysable Polyrotaxane,”Biomaterials,23,4041 (2002).
Wesslen, B., Kober, M., Freij-Larsson, C., Ljungh, A. and Paulsson, M., “Protein Adsorption of Poly(ether urethane) Surfaces Modified by Amphiphilic and Hydrophilic Polymers,”Biomaterials,15, 278 (1994).
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Kim, YW., Kim, JJ. & Kim, Y.H. Surface characterization of biocompatible polysulfone membranes modified with poly(ethylene glycol) derivatives. Korean J. Chem. Eng. 20, 1158–1165 (2003). https://doi.org/10.1007/BF02706955
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DOI: https://doi.org/10.1007/BF02706955