Abstract
It is shown for the first time that the content of ubiquinone of liver increases (2.5 fold) on dietary administration of the widely-used industrial Plasticizer diethylhexyl Phthalate to the rat. The increase is localized almost entirely in mitochondria in which the concentration of the quinone Per mg Protein is 1.7 times the control. IncorPoration of the radioactive Precursor (acetate) reveals that the biosynthesis of ubiquinone is increased in the livers of Plasticizer-administered animals. The rate of degradation is not altered.
Similar content being viewed by others
Abbreviations
- DEHP:
-
Di(2-ethylhexyl) Phthalate
- HMGCoA:
-
3-hydroxy 3-methyl glutaryl coenzyme A
References
Abe, K., Kattayama, K., Ikenoya, S., Takada, M., Yuzuriha, T., Hanamura, K., Nakamura, T., Yusuda, K., Yoshida, S., Watson, B. and Kogure, K. (1981) inBiochemical and Clinical AsPects of Coenzyme Q (eds K. Folkers and Y. Yamamura) (Amsterdam: Elsevier) Vol. 3,tP. 53.
Cenedella, R. J. (1980)Biochem. Pharmacol.,29, 2751.
Edwin, E. E., Bunyan, J., Green, J. and Diplock, A.T. (1962)Br. J. Nutr.,16, l35.
Ganning, A. E., Brunk, U. and Dallner, G. (1983)Biochim. BioPhys Acta.,763, 72.
Gornall, A. G., Bardawill, G. J. and David, M. M. (1949)J. Biol. Chem.,177, 751.
Joshi, V. C, Jayaraman, J. and Ramasarma, T. (1963)Indian J. Exp. Biol.,1, 113.
Joshi, V. C. and Ramasarma, T. (1966)Biochim. BioPhys. Acta.,115, 294.
Krishnaiah, K. V., Joshi, V. C. and Ramasarma, T. (1967a)Arch. Biochem. BioPhys.,121, 147.
Krishnaiah, K. V., Inamdar, A. R. and Ramasarma, T. (1967b)Biochem. BioPhys. Res. Commun.,27, 474.
Krishnaiah, K. V. and Ramasarma, T. (1970)Biochem. J.,116, 321.
Krishnakantha, T. P.and Kurup, C. K. R. (1974)Indian J. Biochem. BioPhys.,11, 51.
Kurup, C. K. R., Aithal, H. N. and Ramasarma, T. (1970)Biochem. J.,116, 773.
Nair, N. and Kurup, C. K. R. (1986)Biochem. Pharmacol.,35, 3441.
Philips, W. E. J., Lakshmanan, M. R. and Brien, R. L. (1968)Can. J. Physiol. Pharmacol.,46, 81.
Ramasarma, T. (1967)Prog. Pharmacol.,2, 56.
Ramasarma, T. (1968)Adv. LiPidRes.,6, 107.
Ramasarma, T. (1972)Curr. ToPics Cell. Reg.,6, 169
Ramasarma, T. (1985a) inCoenzyme Q (ed. G. Lenaz) (Chichester: John Wiley) P. l31.
Ramasarma, T. (1985b) inCoenzyme Q (ed. G. Lenaz) (Chichester: John Wiley) P. 67.
Reddy, J. K., Moody, D. E., Azarnoff, D. L. and Rao, M. S. (1976)Life Sci.,18, 941.
Saikumar, P. and KuruP, C. K. R. (1984)Biochem. J.,224, 955.
Sastry, P. S., Jayaraman, J. and Ramasarma, T. (1961)Nature (London),189, 557.
Thomas, J. A., Darby, T. D., Wallin, R. F., Garvin, P. J. and Martis, L. (1978)Toxicol. APPl. Pharmacol.,45, 1.
Volpe, J. J. and Obert, K. A. (1982)J. Neurochem.,38, 931.
Warren, J. R., Lalwani, N. D. and Reddy, J. K. (1982)Environ. Health PersPect.,45, 35.
Waterlow, J. C., Garlick, P. J. and Millward, D. J. (1978)Protein Turnover in Mammalian Tissues and in the whole Body (Amsterdam: North Holland).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nair, N., Kurup, C.K.R. Increase in hepatic ubiquinone on administration of diethylhexyl phthalate to the rat. J. Biosci. 11, 391–397 (1987). https://doi.org/10.1007/BF02704688
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02704688