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Journal of Biosciences

, Volume 8, Issue 1–2, pp 239–251 | Cite as

Cyclic peptides — Small and big and their conformational aspects

  • C. Ramakrishnan
  • P. K. C. Paul
  • K. Ramnarayan
Article

Abstract

Cyclic peptides form an interesting class of compounds for study by conformational analysis, by virtue of their unique conformational features and biological properties. The small cyclic peptides having 3–6 peptide units in their ring, show a variety of conformational characteristics such as occurrence ofcis peptide units, flexibility of peptide dimension and variety in hydrogen bonding. The different possible conformations of cyclic tri- and hexa-peptides are given and certain specific conformational features are discussed for cyclic tetra and pentapeptides. For higher cyclic peptides, the hydrogen bonding requirement for stability of the backbone of the ring, is seen to be kept to a minimum. These various features and their significance are examined and discussed in the light of energy minimization studies and analysis of available experimental data.

Keywords

Cyclic peptides hydrogen bonding symmetry cyclic hexapeptides energy minimization peptide conformation 

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Copyright information

© Indian Academy of Sciences 1985

Authors and Affiliations

  • C. Ramakrishnan
    • 1
  • P. K. C. Paul
    • 1
  • K. Ramnarayan
    • 1
  1. 1.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia

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