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Journal of Biosciences

, Volume 8, Issue 1–2, pp 15–23 | Cite as

A critique of the utility of the prediction of protein secondary structure

  • Gerald D. Fasman
Article

Abstract

The Chou-Fasman predictive algorithm for determining the secondary structure of proteins from the primary sequence is reviewed. Many examples of its use are presented which illustrate its wide applicability, such as predicting (a) regions with the potential for conformational change, (b) sequences which are capable of assuming several conformations in different environments, (c) effects of single amino acid mutations, (d) amino acid replacements in synthesis of peptides to bring about a change in conformation, (e) guide to the synthesis of polypeptides with definitive secondary structure,e.g. signal sequences, (f) conformational homologues from varying sequences and (g) the amino acid requirements for amphiphilicα-helical peptides.

Keywords

Protein structure prediction secondary structures structure secondary proteins 

Abbreviations used

PTH

Parathyroid hormone

RER

rough endoplasmic reticulum

CRF

corticotropin releasing factor

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Copyright information

© Indian Academy of Sciences 1985

Authors and Affiliations

  • Gerald D. Fasman
    • 1
  1. 1.Graduate Department of BiochemistryBrandeis UniversityWalthamUSA

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