We have investigated the origin of genes, the genetic code, proteins and life using six indices (hydropathy, α-helix, β-sheet and β-turn formabilities, acidic amino acid content and basic amino acid content) necessary for appropriate three-dimensional structure formation of globular proteins. From the analysis of microbial genes, we have concluded that newly-born genes are products of nonstop frames (NSF) on antisense strands of microbial GC-rich genes [GC-NSF(a)] and from SNS repeating sequences [(SNS)n] similar to the GC-NSF(a) (S and N mean G or C and either of four bases, respectively). We have also proposed that the universal genetic code used by most organisms on the earth presently could be derived from a GNC-SNS primitive genetic code. We have further presented the [GADV]-protein world hypothesis of the origin of life as well as a hypothesis of protein production, suggesting that proteins were originally produced by random peptide formation of amino acids restricted in specific amino acid compositions termed as GNC-, SNS and GC-NSF(a)-0th order structures of proteins. The [GADV]-protein world hypothesis is primarily derived from the GNC-primitive genetic code hypothesis. It is also expected that basic properties of extant genes and proteins could be revealed by considerations based on the scenario with four stages
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Dill K A 1990 Dominant forces in protein folding;Biochemistry 29 7133–7155
Gesteland R F, Cech T R and Atkins J F 1999The RNA world (New York: Cold Spring Harbor Laboratory Press)
Gilbert W 1986 The RNA world;Nature (London) 319 618
Gilbert W, de Souza S J and Long M 1997 Origins of genes;Proc. Natl. Acad. Sci. USA 94 7698–7703
Guerrier-Takada C, Gardiner K, Marsh T, Pace N and Altman S 1983 The RNA moiety of ribonuclease P is catalytic subunit of the enzyme;Cell 35 849–857
Ikehara K 1998a Origin and evolution of the genetic code (based on the novel SNS hypothesis) (in Japanese);Seibutukagaku 50 44–54
Ikehara K 1998b A possible evolutionary pathway of the genetic code deduced from the SNS hypothesis;Viva Origino 26 311–320
Ikehara K 1999 Is the RNA-world hypothesis of prebiotic evolution correct? (life was originated from the prebiotic protein world!) (in Japanese);Seibutukagaku 51 43–53
Ikehara K 2000 Life was born from proteins!?—[GADV]-protein world hypothesis—(in Japanese);Kagaku 55 14–19
Ikehara K, Amada F, Yoshida S, Mikata Y and Tanaka A 1996 A possible origin of newly-born bacterial genes: significance of GC-rich nonstop frame on antisense strand;Nucleic Acids Res. 24 4249–4255
Ikehara K and Okazawa E 1993 Unusually biased nucleotide sequences on sense strands ofFlavobacterium sp. genes produce nonstop frames on the corresponding antisense strands;Nucleic Acids Res. 21 2193–2199
Ikehara K, Omori Y, Arai R and Hirose A 2002 A novel theory on the origin of the genetic code: a GNC-SNS hypothesis;J. Mol. Evol. (in press)
Ikehara K and Yoshida S 1998 SNS hypothesis on the origin of the genetic code;Viva Origino 26 301–310
Jimenez-Sanches A 1995 In the origin and evolution of the genetic code;J. Mol. Evol. 41 712–716
Kruger K, Grabowski P J, Zaug A J, Sands J, Gottschling D E and Cech T R 1982 Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence ofTetrahymena;Cell 31 147–157
Miller S L and Orgel L E 1975The origin of life on the earth (New York: Prentice-Hall)
Ohno S 1970Evolution by gene duplication (Heiderberg: Springer)
Osawa S 1995Evolution of the genetic code (Oxford: Oxford University Press)
Stryer L 1988Biochemistry 3rd edition (New York: W H Freeman)
Sueoka N 1988 Directional mutation pressure and neutral molecular evolution;Proc. Natl. Acad. Sci. USA 85 2653–2657
Voet D, Voet J G and Pratt C W 1999Fundamentals of biochemistry (New York: John Wiley)
This review is a modified English version of the paper, which was written in Japanese and published inViva Origino 2001 29 66–85.
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Ikehara, K. Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis. J Biosci 27, 165–186 (2002). https://doi.org/10.1007/BF02703773
- GNC-SNS primitive genetic code hypothesis
- origin of genes
- origin of genetic code
- origin of life
- origin of proteins