Abstract
Oral administration of sodium orthovanadate restored blood glucose to normal levels in streptozotocin-induced diabetic rats. To establish the safety dose and to evaluate the side effects of over dose, if any, different doses of vanadium were used in the present study. Low concentrations of vanadium (0.1 and 0.3 mg/ml in drinking water) restored blood glucose, urea, cholesterol and the status of liver pathophysiological enzymes to normal levels in experimental rats. High vanadate treatment proved to be toxic not only to diabetic but also to normal rats as evidenced from the observations on the blood urea, plasma and liver glutamate oxaloacetate transaminase and glutamate pyruvate transaminase. Low vanadate treatment restored body homeostasis of diabetic rats and was found to be nontoxic to normals.
Similar content being viewed by others
Abbreviations
- TCA:
-
Trichloroacetic acid
- GOT:
-
glutamate oxaloacetate transaminase
- GPT:
-
glutamate pyruvate transaminase
- MDA:
-
malondialdehyde
- SOD:
-
superoxide dismutase
- CAT:
-
catalase
References
Cynamon, H. A., Isenbrerg, J. N. and Nguyen Co. A. (1985)Clin. Chim. Acta,151, 169.
Feingold, K. R., Fulford, M., Zsigmondgyula, M. H., Arthur, L. R., Steven, S. and Marvin, D. (1982)Lessons Anim. Diabetes (Lect. Discus. Int. Workshop) 556.
George, K. A. and Augusti, K. T. (1978)Indian J. Exp. Biol.,16, 1952.
Gil, J., Miralpeix, M., Carreras, J. and Bartrons, R. (1988)J. Biol. Chem.,263, 1868.
Golden, M. H. N. and Golden, B. E. (1981)Br. Med. Bull.,37, 31.
Heyliger, C. E., Tashiliani, A. G. and McNeil, J. H. (1985)Science,227, 1474.
Jorda, A., Cado, J. and Grisolia, S., (1981)Enzyme,26, 240.
Kanthasamy, A., Rathinavelu, A. and Govindasamy, S. (1986)Contemp. Themes Biochem.,6, 318.
Loven, D., Schedl, H., Wilson, H., Daanbees, T. T., Stegink, D. L., Diekus, M. and Oberley, L. (1986)Dibetes,35, 503.
Meyerovitch, J., Farfel, Z., Sack, J. and Shechter, Y. (1987)J. Biol. Chem.,262, 6658.
Misra, H. P. and Fridovich, I. (1972)J. Biol. Chem.,247, 3170.
Mohan Rao, G. M., Morghom, L. O., Kabur, M. N., Ben Mohmud, B. M. and Ashibani, K. (1989)Indian J. Med. Sci.,5, 118.
Natelson, S., Scott, M. L. and Beffa, C. (1951)Am. J. Clin. Pathol.,21, 1423.
Parekh, A. C. and Jung, D. H. (1910)Anal. Chem.,42, 1423.
Sasaki, J. and Matsui, S. (1972)Rinshu Kagaku.,1, 346.
Sato, Y., Hotta, N., Sakamoto, N., Matusoka, S., Ohishi, N. and Yagi, K. (1979)Biochem. Med.,21, 104.
Schwarz, K. and Milne, D. B. (1971)Science,174, 426.
Scott, P. W., Trick, K. D, Lee, L. P. K., Hynie, I., Heick, H. M. C. and Nera, E. A. (1984)Clin. Biochim.,17, 270.
Shechter, Y. and Karlish, S. J. D. (1980)Nature (London),284, 556.
Takhara, S., Hamilton, B. H., Nell, J. V., Kobara, T. Y., Ogura, Y. and Nishimura, E. T. (1960)J. Clin. Invest.,39, 610.
Wohaieb, S. A. and Godin, E. V. (1987)Diabetes,36, 1014.
Wooten, I. D. P. (1965)Microanalysis in medical biochemistry (London: J and A Churchill Ltd.)
Yagi, K. (1987)Chem. Phys. Lipids,45, 337.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sekar, N., William, S., Balasubramaniyam, N. et al. Optimization of sodium orthovanadate to treat streptozotocin-induced diabetic rats. J Biosci 15, 67–75 (1990). https://doi.org/10.1007/BF02703370
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02703370