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Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§

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Abstract

Antileishmanial activity and organ distribution of the antifungal drug Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected withLeishmania donovani. Results indicate that Amphotericin-B in the liposomised form is significantly more active than the free form. This increase in the activity is perhaps related to the reduced drug toxicity rather than the altered drug distribution at the site of infection.

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Abbreviations

Amp-B:

Amphotericin-B

Chol:

cholesterol

SPC:

soya phosphatidylcholine

EPC:

egg phosphatidylcholine

HPLC:

high pressure liquid chromatography

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Authors and Affiliations

  1. Division of Membrane Biology, Central Drug Research Institute, 226 001, Lucknow, India

    Imran Ahmad, Anshu Agarwal, Ajay Pal, P. Y. Guru, B. K. Bachhawat & C. M. Gupta

  2. Division of Parasitology, Central Drug Research Institute, 226 001, Lucknow, India

    Ajay Pal & P. Y. Guru

  3. Liposome Research Centre, University of Delhi, South Campus, Benito Juarez Road, 110 021, New Delhi, India

    Imran Ahmad & B. K. Bachhawat

Authors
  1. Imran Ahmad
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  2. Anshu Agarwal
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  3. Ajay Pal
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  4. P. Y. Guru
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  5. B. K. Bachhawat
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  6. C. M. Gupta
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CDRI communication No. 4789

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Ahmad, I., Agarwal, A., Pal, A. et al. Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§ . J Biosci 16, 217–221 (1991). https://doi.org/10.1007/BF02703287

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  • DOI: https://doi.org/10.1007/BF02703287

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