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Control of transcription initiation

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Abstract

Mechanism of control of transcription initiation have expanded far beyond the classical operon concept. Control elements are multipartite and well separated from each other. Thetrans-factors bound to these sites make contacts with RNA polymerase: promoter complexes by DNA bending or looping to influence the initiation event. Activators and repressors are like two faces of the same coin and their function depends on the site of action, mode of interaction with DNA and also the nutritional status of the cell.

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Authors and Affiliations

  1. Centre for Generic Engineering, Indian Institute of Science, 560 012, Bangalore, India

    V. Nagaraja

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  1. V. Nagaraja
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Based on the lecture given at the Symposium on “Regulation of Gene Expression” held in Bangalore on January 20–21, 1992.

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Nagaraja, V. Control of transcription initiation. J Biosci 18, 13–25 (1993). https://doi.org/10.1007/BF02703034

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  • DOI: https://doi.org/10.1007/BF02703034

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