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Changes in insulin receptor, hexokinase and NADPH producing enzymes in Choroid plexus during experimental diabetes

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Abstract

The activities of insulin receptor and the enzymes hexokinase (EC 2.7.1.1) and NADP-dependent malic enzyme (EC1.1.1.40), glucose 6-phosphate dehydrogenase (EC 1.1.1.49) and isocitrate dehydrogenase (EC 1.1.1.42) were measured in rat choroid plexus in alloxan induced diabetes. A significant decrease was observed in the activities of all the enzymes except isocitrate dehydrogenase and also the choroid plexus insulin receptor activity was decreased. A reversal of the efect was observed with insulin administration to diabetic rats. It may be concluded that the enzymes of choroid plexus together with insulin receptor are directly controlled by-the concentration of insulin.

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Abbreviations

CSF:

Cerebrospinal fluid

IR:

insulin receptor

HK:

hexokinase

IDH:

isocitrate dehydrogenase

ME:

malic enzyme

STD:

short-term diabetic

STD + I, STD +:

insulin

LTD, long-term:

diabetic

LTD +I, LTD +:

insulin

G6PDH:

glucose 6-phosphate dehydrogenase

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Authors and Affiliations

  1. Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India

    Mansoor A. Ansari, Biharil Gupta & Najma Z. Baquer

Authors
  1. Mansoor A. Ansari
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  2. Biharil Gupta
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  3. Najma Z. Baquer
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Ansari, M.A., Gupta, B. & Baquer, N.Z. Changes in insulin receptor, hexokinase and NADPH producing enzymes in Choroid plexus during experimental diabetes. J. Biosci. 18, 337–343 (1993). https://doi.org/10.1007/BF02702991

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  • DOI: https://doi.org/10.1007/BF02702991

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