Abstract
Penicillin at concentrations non-inhibitory to the vegetative growth was found to inhibit sporulation inBacillus polymyxa 2459. The effect of penicillin was shown to be at the level of spore-specific mucopeptide synthesis. Penicillin had no effect on the early events such as DNA and protein synthesis in sporogenesis The sensitive period of inhibition was between T0 to T2 hours of sporulation.
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References
Fitz-James, P. C. (1963)Regulations chez les microorganismes ed M. J. C. Senez (Paris: Centre National de la Recherche Scientifique), p 529.
Hitchins, A. D. and Slepecky, R. A. (1969)J. Bacteriol.,97, 1513.
Janssen, F. W., Lund A. J. and Anderson, L. E. (1958)Science,127, 26.
Lawrence, P. J., (1974)Antimicrobial agents and chemotherapy,6, 815.
Mandelstam, J. (1976)Proc R Soc., (London),B193, 86.
Pearce, S. M. and Fitz-James, P. C. (1971)J. Bacteriol.,105, 339.
Pitel, D. W. and Gilvarg C. (1970)J. Biol. Chem.,247, 6711.
Rinderknecht, H., Geokas, M. C., Silverman, P. and Haverback, B. J. (1968)Clin. Chim. Acta,21, 197.
Sterlini, J. M. and Mandelstam, J. (1969)Biochem. J. 113, 29.
Torriani, A. (1960)Biochem. Biophys. Acta,38, 460.
Vinter, V. (1963)Folia Microbiol. Praha.,8, 147.
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Goel, A.K., Jayaraman, K. Inhibitory effect of penicillin on spore-specific functions inBacillus polymyxa 2459. J Biosci 1, 91–97 (1979). https://doi.org/10.1007/BF02702891
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DOI: https://doi.org/10.1007/BF02702891