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The effect of luteinizing hormone releasing hormone and anti-luteinizing hormone releasing hormone antibodies on chorionic gonadotropin and progesterone secretion by human placental villiin vitro

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Abstract

Gonadotropin releasing hormone has been located and found to be secreted by the human placenta in culture. Addition of the releasing hormone upto 1μg concentration in the placental cultures brings about stimulation of chorionic gonadotropin and progesterone secretion. Higher amounts of the decapeptide has an inhibitory influence on both the gonadotropin and the steroid production. The action of the releasing hormone on the placenta could be blocked by the anti-luteinizing hormone releasing hormone monoclonal antibodies indicating a possible site of action of the antibodies for control of fertility

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Abbreviations

GnRH:

Gonadotropin releasing hormone

LHRH:

luteinizing hormone releasing hormone

hCG:

human chorionic gonadotropin

CG:

chorionic gonadotropin

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Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, 110029, New Delhi, India

    A. Malik, S. Kaul & C. Das

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  1. A. Malik
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  2. S. Kaul
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  3. C. Das
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Malik, A., Kaul, S. & Das, C. The effect of luteinizing hormone releasing hormone and anti-luteinizing hormone releasing hormone antibodies on chorionic gonadotropin and progesterone secretion by human placental villiin vitro . J. Biosci. 10, 67–74 (1986). https://doi.org/10.1007/BF02702841

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