Abstract
Levels of lipid peroxides in rat caecum, blood, liver and kidney and the capacity of tissue homogenates to form lipid peroxidesin vitro was enhanced after caecal amoebiasis in rats produced byEntamoeba histolytica (IB-1). The activity of hepatic drug-metabolizing enzymes in post-mitochondrial fraction and the cytochrome P450 contents in microsomal fraction decreased significantly, while lysosomal enzymes such as acid phosphatase, acid ribonuclease and cathepsin B showed an increase in the liver homogenates of infected animals. These changes were reversed following treatment with the antiamoebic drug, metronidazole
Similar content being viewed by others
References
Cochin, J. and Axelrod, J. (1959)J. Pharmacol. Exp. Therap.,125, 105.
De Duve, C, Pressman, B. C., Gianetto, R., Wattiaux, R. and Applemans, F. (1955)Biochem. J.,60, 604.
Dutta, G. P. and Srivastava, R. V. N. (1974)Indian J. Med. Res.,62, 919.
Gevondyan, S. A. and Gevondyan, V. S. (1974)Trans. Staravrop. S-Kh. Instt.,37, 52.
Gill, N. G., Ganguly, N. K., Mahajan, R. C., Bhusnurinath, S. R. and Dilawari, J. B. (1983a)Indian J. Med. Res.,78, 489.
Gill, N. G., Ganguly, N. K., Mahajan, R. C., Bhusnurinath, S. R. and Dilawari, J. B. (1983b)Trans. R. Soc. Trop. Med. Hyg.,77, 53.
Hiramitsu, T., Hasegawa, Y., Hirata, K., Nishigaki, I. and Yagi, K. (1976a)Experentia,32, 622.
Hiramitsu, T., Majima, Y., Hasegawa, Y., Hirata, K. and Yagi, K. (1976b)Experentia,32, 1324.
Kalish, G. H., Di Luio, N. R. (1966)Science,152, 1390.
Kato, R. and Gilette, J. R. (1965)J. Pharmacol. Exp. Therap.,150, 279.
Krishna Prasad, B. N. and Bansal, I. (1982)Indian J. Parasitol.,6, 97.
Krishna Prasad, B. N. and Bansal, I. (1983)Trans. R. Soc. Trop. Med. Hyg.,77, 271.
Mycek, M. J. (1970)Methods Enzymol.,19, 285.
Neals, R. A. (1951)Trans. R. Soc. Trop. Med. Hygiene.,44, 439.
Nishigaki, L, Hagihara, M., Hiramitsu, M., Izawa, Y. and Yagi, K. (1980)Biochem. Med.,24, 185.
Ohkawa, H., Ohishi, N. and Yagi, K. (1979)Anal. Biochem.,95, 351.
Omura, T. and Sato, R. (1964)J. Biol. Chem.,239, 2370.
Sato, Y., Hotta, N., Sakamoto, N., Matsuoka, S., Ohishi, N. and Yagi, K. (1979)Biochem. Med.,21, 104.
Sharma, S. C., Mukhtar, H., Sharma, S. K. and Krishna Murti, C. R. (1972)Biochem. Pharmacol.,21, 1210.
Singh, B. N., Das, S. R. and Dutta, G. P. (1973)Curr. Sci.,42, 227.
Suematsu, T., Kamada, T., Abe, H., Kikuchi, S. and Yagi, K. (1977)Clin. Chim. Acta,79, 267.
Tappel, A. L., Sawant, P. L. and Shibko, S. (1963) inLysosomes, (eds A. V. S. Dereuck and M. P. Cameron), (London: Academic Press) p. 78.
Weinbach, E. C., Takeuchi, T., Claggett, C. E., Inohue, F. and Diamond, L. S. (1980)Azch. Invest. Medica (Max),10, (Suppl. 1), 75.
Wills, E. D. (1971) Biochem. J.,123, 983.
Wills, E. D. and Wilkinson, A. E. (1966)Biochem. J.,99, 657.
Wright, P. J., Leathwood, P. D. and Plummer, D. T. (1972)Enzymologia,42, 459.
Yagi, K. (1976)Bio. Med.,15, 212.
Author information
Authors and Affiliations
Additional information
C.D.R.I. Communication No. 3707.
Rights and permissions
About this article
Cite this article
Bardhan, P., Bansal, I., Prasad, B.N.K. et al. Biochemical lesions in liver and kidney after caecal amoebiasis in rats byEntamoeba histolytica and their reversal by antiamoebic drugs. J. Biosci. 10, 21–27 (1986). https://doi.org/10.1007/BF02702836
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02702836