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Modified bases in transfer RNA

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Abstract

Transfer RNA is uniquely enriched with modified bases. A large body of information has accumulated about the occurrence, nature and distribution of modified bases in tRNA. But similar investigations on the enzymes involved in this post-transcriptional modification have been hampered by the instability of the enzymes and lack of suitable substrates. The present review summarises briefly, the occurrence and methods of detection of modified bases, the enzymes involved in their formation and also certain suggestive evidence for the role of modification in cellular metabolism.

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Abbreviations

mcm5U:

5-Methoxycarbonyl methyl uridine

cmnm5U:

5-carboxy methyl aminomethyl uridine

acp3U:

3-(3-amino-3-carboxy propyl) uridine

m5C:

5-methylcytosine

ac4C:

N4-acetyl cytidine

s2C:

2-thiocytidine

i6A:

N6-isopentenyl adenosine

ms2i6A:

2-methyl thio-N6-isopentenyl adenosine

t6 A:

(N-(9-Β-D-ribofuranosyl purin-6 yl) carbamoyl) threonine

mlG:

1-methyl guanine

m2 G:

2-methyl guanine

m 22 G:

N2N2-dimethyl guanine

m7 G:

7-methyl guanine

NMR:

nuclear magnetic resonance

HPLC:

high pressure liquid chromatography

AMV:

avian myeloblastosis virus

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Brahmachari, V., Ramakrishnan, T. Modified bases in transfer RNA. J. Biosci. 6, 757–770 (1984). https://doi.org/10.1007/BF02702718

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  • DOI: https://doi.org/10.1007/BF02702718

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