Abstract
Methionine deficiency in rats caused significant decrease in the concentration of many sulphated glycosaminoglycans in the aorta and other tissues, while administration of excess methionine caused an increase in these constituents. The activity of some important biosynthetic enzymes decreased in methionine deficiency and increased on administration of excess methionine. No uniform pattern was observed in the changes in the activity of enzymes concerned with degradation of glycosaminoglycans. The concentration of 3′-phosphoade-nosine 5′-phosphosulphate and the activities of the sulphate activating system and sulpho-transferase were decreased in methionine deficiency, while feeding excess methionine did not affect these parameters as compared to controls.
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Abbreviations
- GAG:
-
glycosaminoglycans
- VLDL or LDL:
-
VDL, very low, or low or high density lipoproteins
- PAP,3’:
-
-phosphoadenosine-5′ phosphosulphate
References
Aoyama, Y. Yoshida, A. and Ashida, K. (1969)J. Nutr.,97, 348.
Aoyama, Y. and Ashida, K. (1972)J. Nutr.,102, 1025.
Aoyama, Y. and Ashida, K. (1978)J. Nutr. Rep. Inst.,17, 463.
Bennet, C. A. and Franklin, N. L. (1967)Statistical Analysis in Chemistry and Chemical Industry (New York: John Wiley and Sons, Inc.)
Bitter, J. and Muir, H. M. (1962)Anal. Biochim.,4, 330.
Folin, O. and Ciocalteu, V. (1927)J. Biol. Chem.,73, 627.
Iverius, P. H. (1968)J. Biol. Chem.,73, 627.
Iverius, P. H. (1968)Clin. Chem. Aota.,20, 261.
Iverius, P. H. (1970)in Chemistry and Molecular Biology of Intercellular Matrix, ed. E. A. Balate (London: Acadamic Press),3, 1615.
Iverius, P. H. (1973) Possible role of glycosaminoglycans in the genesis of atherosclerosis, inAtherosclerosis: Initiation factors, Ciba foundation symposium 12, Elsevier Amsterdam 185.
Kawai, Y. and Anno, K. (1971)Biochem. Biophys. Acta,242, 428.
Laurent, T. C, Bjork, I. Pietruszkiewiez, A. and Person, H. (1963)Biochem. Biophys. Acta,78, 351.
Laurent, T. C. (1968) inThe Chemical Physiology of the Mucopolysaccharides, ed. G. Quintarelit (Boston: Little, Brown), 153.
Leelamma, S. and Kurup, P. A. (1978)Indian J. Exp. Biol,16, 36.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951)J. Biol. Chem.,193, 265.
Menon, P. V. G. and Kurup, P. A. (1975)Indian J. Biochem. Biophys.,12, 389.
Menon, P. V. G. and Kurup, P. A. (1976)Artery,21, 219.
Menon, P. V. G. and Kurup, P. A. (1976)Indian J. Biochem. Biophys.,13, 146.
Oser, B. L. (1965) inHawks Physiological Chemistry, (New York: McGraw Hill, 132.
Pogell, B. M. and Gryder, R. M. (1957)J. Biol. Chem.,228, 701.
Sandhyavathy Bai, and Kurup, P. A. (1976)Indian J. Exp. Biol.,14, 1107.
Srinivasan, H., Srinivaas, L. and Rao, P. B. R. (1972)Nutr. Rep. Int.,6, 145.
Srinivasan, S. R., Dolan, P., Radhakrishna Murthy, B. and Berenson, G. S. (1972)Atherosclerosis,16 95.
Strominger, J. L., Maxwell, E. S., Axelford, J. and Kalckar, H. M. (1957)J. Biol. Chem.,224, 79.
Sudhakaran, P. R. and Kurup, P. A. (1974)J. Nutr.,104, 871.
Svejear, J. and Robertson, W. E. B. (1967)Anal. Biochem.,18, 333.
Udupa, K. N., Woessner, J. F. and Dunphy, J. E. (1956)Surg. Gynecol. Obset.,102, 639.
Vankempen, G. M. J. and Jansen, G. C. I. M. (1972)Anal. Biochem.,46, 438.
Vankempen, G. M. J. and Jansen, G. S. I. M. (1973)Anal. Biochem.,51, 324.
Warnick, R. G. and Albers, J. T. (1978)J. Lipid. Res.,19, 65.
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Kurup, G.M., Kurup, P.A. Metabolism of glycosaminoglycans in rats during methionine deficiency and administration of excess methionine. J. Biosci. 4, 95–104 (1982). https://doi.org/10.1007/BF02702585
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DOI: https://doi.org/10.1007/BF02702585