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Significance of zinc in nephrotoxicity of contrast media used in imaging diagnostics of the cardiovascular system

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Abstract

Nephrotoxicity is an undesirable reaction of contrast media used in X-ray or magnetic resonance diagnostics. In addition to a direct toxic effect on renal tubules, the hemodynamic factor is considered to be the main cause of kidney damage and malfunction. The factors that increase the probability of a nephrotoxic effect of contrast media include oldage, diabetes, arterial hypertension, circulatory system insufficiency, neoplastic diseases, and prior kidney damage. Decreased serum zinc is observed in all those conditions. In this article, the influence of contrast media on zinc homeostasis and the possibility of a nephrotoxic reaction caused by these agents is discussed.

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Authors and Affiliations

  1. Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Prószkowska Street 76, 45-758, Opole, Poland

    Sławomir Tubek & Iwona Tubek

  2. Diagnostics Imaging Laboratory, Krakowska Street 36, 47-100, Strzelce Opolskie, Poland

    Iwona Tubek

Authors
  1. Sławomir Tubek
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  2. Iwona Tubek
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Correspondence to Sławomir Tubek.

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Tubek, S., Tubek, I. Significance of zinc in nephrotoxicity of contrast media used in imaging diagnostics of the cardiovascular system. Biol Trace Elem Res 117, 1–5 (2007). https://doi.org/10.1007/BF02698078

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  • DOI: https://doi.org/10.1007/BF02698078

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