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A mathematical model for the regulation of tryptophan promoter

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Abstract

Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.

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Authors and Affiliations

  1. Department of Genetic Engineering, Sung Kyun Kwan University, 300 Chunchun-Dong, 440–746, Suwon, Korea

    Tai Hyun Park

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  1. Tai Hyun Park
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Park, T.H. A mathematical model for the regulation of tryptophan promoter. Korean J. Chem. Eng. 11, 282–289 (1994). https://doi.org/10.1007/BF02697395

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  • DOI: https://doi.org/10.1007/BF02697395

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