Abstract
This article suggests that process development, consisting of process research and innovation, pilot plant, technology transfer and manufacturing, will play a key role in the evolution of chemical engineering as a profession. By integrating science, engineering and management with a multiscale approach, process development helps break down artificial barriers, leading to performance optimization from an enterprise-wide perspective.
Similar content being viewed by others
References
Arora, A., Landau, R. and Rosenberg, N., “Chemicals and Long-Term Economic Growth”, John Wiley & Sons, New York (1998).
Barton, K. P., Irdam, E. A., Seymour, C. B. and Behling, J. R., “Partnering for Success: ACE Teams in Drug Process Development”, AIChE Annual Meeting, Los Angeles, Paper 274c (2000).
Basu, P. K., Mack, R. and Vinson, J. M., “Consider A New Approach to Pharmaceutical Process Development”,Chem. Eng. Prog.,95(8), 82 (1999).
Basu, P. K., “Pharmaceutical Process Development is Different”,Chem. Eng. Prog.,94(9), 75 (1998).
Berry, D. A., Dye, S. R. and Ng, K. M., “Synthesis of Drowning-Out Crystallization-Based Separations”,AIChE J.,43, 91 (1997).
Berry, D. A. and Ng, K. M., “Separation of Quaternary Conjugate Salt Systems by Fractional Crystallization”,AIChE J.,42, 2162 (1996).
Biegler, L. T., Grossmann, I. E. and Westerberg, A. W., “Systematic Methods of Chemical Process Design”, Prentice Hall, Upper Saddle River, NJ (1997).
Bisio, A. and Kabel, R. L., eds., “Scaleup of Chemical Processes: Conversion from Laboratory Scale Tests to Successful Commercial Size Design”, Wiley, New York, NY (1985).
Cesar, M. A. B. and Ng, K. M., “Improving Product Recovery in Fractional Crystallization Processes: Retrofit of an Adipic Acid Plant”,Ind. Eng. Chem. Res.,38, 823 (1999).
Chang, W.-C. and Ng, K. M., “Synthesis of the Processing System Around a Crystallize”,AIChE J.,44, 2240 (1998).
Cherney, S. and Rappaport, J., “International Technology Transfer”, AIChE Spring Meeting, Houston, Session 101 (2001).
Davis, W P., “Transfer of Pharmaceutical Processes to Overseas Contract Manufacturers”, AIChE Spring Meeting, Houston, Paper 101a (2001).
Doherty, M. F. and Malone, M. F., “Conceptual Design of Distillation Systems”, McGraw Hill, New York (2001).
Douglas, J. M., “Conceptual Design of Chemical Processes”, McGraw-Hill, New York (1988).
Dye, S. R. and Ng, K. M., “Bypassing Eutectics with Extractive Crystallization: Design Alternatives and Tradeoffs”,AIChE J.,41, 1456 (1995a).
Dye, S. R. and Ng, K. M., “Fractional Crystallization: Design Alternatives and Tradeoffs”,AIChE J.,41, 2427 (1995b).
Economist, Nanoelectronics, May 10, p.67 (2003).
Grossmann, I. E. and Westerberg, A. W., “Research Challenges in Process Systems Engineering”,AIChE J.,46, 1700 (2000).
Hoyle, W, ed., “Pilot Plants and Scale-up of Chemical Processes”, I and II, The Royal Society of Chemistry, Cambridge, UK (1997).
Kelkar, V. V. and Ng, K. M., “Development of Fluidized Catalytic Reactors-Screening and Scale-up”,AIChE J.,48, 1486 (2002).
Kelkar, V. V. and Ng, K. M., “Screening Procedure for Synthesizing Isothermal Multiphase Reactors”,AIChE J.,44, 1563 (1998).
Kelkar, V. V. and Ng, K. M., “Screening of Multiphase Reactors for Nonisothermal Multiple Reactions”,AIChE J.,46, 389 (2000).
Kim, C. J., “Supply Chain Management in Process Industry”, keynote presentation at PSE Asia, Taipei (2002).
Kind, M., “Product Engineering”,Chem. Eng. Processing,38, 405 (1999).
Kwok, K. S., Chan, H. C, Chan, C. K. and Ng, K M., “Experimental Determination of Solid Liquid Equilibrium Phase Diagrams”, manuscript in preparation (2003).
Landau, R., “Education: Moving from Chemistry to Chemical Engineering and Beyond”,Chem. Eng. Prog.,93(1), 52 (1997).
Lerou, J. J. and Ng, K. M., “Chemical Reaction Engineering: A Multiscale Approach to a Multiobjective Task”,Chem. Eng. Sci.,51, 1595 (1996).
Mansfield, S., “Engineering Design for Process Facilities”, McGraw-Hill, New York, NY (1993).
McConville, F X., “The Pilot Plant Real Book”, FXM Engineering and Design, Worcester, MA (2002).
Merrow, E. W., “Linking R&D to Problems Experienced in Solids Processing”,Chem. Eng. Prog.,81(5), 14 (1985).
Moggridge, J. D. and Cussler, E. L., “Introduction to Chemical Product Design”,Chem. Eng. Res. Des.,77, 5 (2000).
Ng, K. M., “A Multiscale-Multifaceted Approach to Process Synthesis and Development”, ESCAPE11, Ed. R. Gani and S. B. Jorgensen, 41, Elsevier (2001).
Ng, K M., “Design and Development of Solids Processes-a Systems Engineering Perspective”,Powder Tech.,126, 205 (2002).
Ng, K. M., “MOPSD: A Framework Linking Business Decision-Making to Product and Process Design”, Paper presented at PSE, Kunming, China (2003).
Palluzi, R. P., “Pilot Plant Design, Construction, and Operation”, McGraw-Hill, New York (1992).
Rajagopal, S., Ng, K. M. and Douglas, J. M., “A Hierarchical Procedure for the Conceptual Design of Solids Processes”,Comp. Chem. Eng.,16, 675 (1992).
Rajagopal, S., Ng, K M. and Douglas, J. M., “Design and Economic Tradeoffs of Extractive Crystallization Processes”,AIChE J.,37, 437 (1991).
Reklaitis, G. V., “Preparation of Chemical Engineers for Manufacturing Leadership in the 21st Century”, Phillips Petroleum Company Lecture Series, Oklahoma State University, Stillwater, OK (2000).
Saban, M. and Dale, B., “Knowledge-Sharing for Technology Transfer in the Chemical Industry: A Case Study AIChE Spring Meeting, Houston, Paper 101d (2001).
Samant, K. D., Berry, D. A. and Ng, K M., “Representation of High-Dimensional, Molecular Solid-Liquid Phase Diagrams”,AIChE J.,46, 2435 (2000).
Samant, K. D. and Ng, K. M., “Effect of Kinetics and Mass Transfer on Design of Extractive Reaction Systems”,AIChE J.,44, 2212 (1998).
Samant, K. D. and Ng, K. M., “Development of Liquid-Phase Agitated Reactors: Synthesis, Simulation, and Scale-up”,AIChE J.,45, 2371 (1999).
Samant, K. D. and Ng, K. M., “Representation of High-Dimensional Solid-Liquid Phase Diagrams of Ionic Systems”,AIChE J.,47, 861 (2001).
Sarafinas, A., Roemmele, R. C. and Eagleton, J. C., “An Integrated Approach to Agricultural Intermediate Process Development”, AIChE Annual Meeting, Los Angeles, Paper 274b (2000).
Schroer, J. W. and Ng, K. M., “Process Paths of Kinetically Controlled Crystallization: Enantiomers and Polymorphs”,Ind. Eng. Chem. Res.,42, 2230 (2003).
Schroer, J. W., Wibowo, C. and Ng, K. M., “Synthesis of Chiral Crystallization Processes”,AIChE J.,47, 369 (2001).
Scriven, L. E., “On the Emergence and Evolution of Chemical Engineering”, in C. K. Colton, “Perspectives in Chemical Engineering Research and Education”,Advances in Chemical Engineering,16, 3 (1991).
Seider, W. D., Seader, J. D. and Lewin, D. R., “Process Design Principles”, Wiley, New York, NY (1999).
Singh, D. J., Samant, K. D. and Ng, K. M., “Design of Homogeneous Biphasic Catalytic Processes”,AIChE J.,48, 1991 (2002).
Snodgrass, J. T., Dalgarno, D. C. and Canning, K., “Analytical Methods Transfer for Early Stage Pharmaceutical Development”, AIChE Spring Meeting, New Orleans, Paper 148g (2003).
Tanguy, D. and Marchal, P., “Relations between the Properties of Particles and Their Process of Manufacture”,Chem. Eng. Res. Des.,74, 715 (1996).
Tirronen, E. and Salmi, T., “Process Development in the Fine Chemical Industry”,Chem. Eng. J.,91, 103 (2003).
Turton, R., Bailie, R. C., Whiting, W. B. and Shaeiwitz, J. A., “Analysis, Synthesis, and Design of Chemical Processes”, Prentice Hall, Upper Saddle River, NJ (1998).
Ung, S. and Doherty, M. F., “Synthesis of Reactive Distillation Systems with Multiple Equilibrium Chemical Reactions”,Ind. Eng. Chem. Res.,34, 2555 (1995).
Wibowo, C., Chang, W.-C. and Ng, K. M., “Design of Integrated Crystallization Systems”,AIChE J.,47, 2474 (2001).
Wibowo, C. and Ng, K. M., “Operational Problems in Solids Processing Plants: Systems View”,AIChE J.,47, 107 (2001).
Wibowo, C. and Ng, K. M., “Synthesis of Bulk Solids Processing Systems”,AIChE J.,45, 1629 (1999).
Wibowo, C. and Ng, K. M., “Unified Approach for Synthesizing Crystallization-based Separation Processes”,AIChE J.,46, 1400 (2000).
Wibowo, C. and Ng, K. M., “Visualization of High-Dimensional Phase Diagrams of Molecular and Ionic Mixtures”,AIChE J.,48, 991 (2002a).
Wibowo, C. and Ng, K. M., “Product-Centered Processing: Chemical-Based Consumer Product Manufacture”,AIChE J.,48, 1212 (2002b).
Wibowo, C. and Ng, K. M., “Workflow for Process Synthesis and Development: Crystallization and Solids Processing”,Ind. Eng. Chem. Res.,41, 3839 (2002c).
Wibowo, C., O'Young, L. and Ng, K. M., “Workflow Management in Chemical Process Development”, manuscript in preparation (2003).
Wibowo, C, Samant, K. D. and Ng, K. M., “High-Dimensional Solid-Liquid Phase Diagrams Involving Compounds and Polymorphs”,AIChE J.,48, 2179 (2002).
Williams, F. and Gibson, D. V., “Technology Transfer, A Communication Perspective”, Sage Publications, Newbury Park, CA (1990).
Wintermantel, K., “Process and Product Engineering: Achievements, Present and Future Challenges”,Chem. Eng. Res. Des.,77, 175 (1999).
Woods, D. R., “Process Design and Engineering Practice”, Prentice Hall, Upper Saddle River, NJ (1995).
Zukoski, C, Armstrong, R. and Rousseau, R., “Discipline at a Crossroads”, a Chemical Engineering Leadership Workshop, Houston (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ng, K.M., Wibowo, C. Beyond process design: The emergence of a process development focus. Korean J. Chem. Eng. 20, 791–798 (2003). https://doi.org/10.1007/BF02697278
Issue Date:
DOI: https://doi.org/10.1007/BF02697278