Skip to main content
SpringerLink
Log in

Comparative analysis of accumulation of chlorine e6 and hematoporphyrin derivatives in subpopulations of peripheral blood lymphocytes

  • Biophysics And Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. G. P. Gurinovich, T. E. Zorina, and Yu. M. Arkatov,Tsitologiya,31, 1058–1063 (1989).

    CAS  Google Scholar 

  2. G. P. Gurinovich, T. E. Zorina, and V. P. Zorin,Izv. Akad. Nauk SSSR. Ser. Fizich.,53, 1153–1156 (1989).

    CAS  Google Scholar 

  3. G. E. Dobretsov, T. N. Baglaev, and S. O. Balyakin,Immunologiya, No. 6, 68–71 (1981).

  4. V. P. Zorin, I. I. Khludeyev, and T. E. Zorina,Eksper. Onkol.,14, 39–43 (1992).

    CAS  Google Scholar 

  5. V. P. Zorin, I. I. Khludeyev, and T. E. Zorina,Biofizika,45, No. 2, 313–319 (2000).

    PubMed  CAS  Google Scholar 

  6. V. P. Savitskii and V. P. Zorin,|Ibid.Biofizika,48, No. 1, 58–62 (2003).

    PubMed  CAS  Google Scholar 

  7. T. J. Dougherty,J. Clin. Laser Med. Surg.,20, 3–7 (2002).

    Article  PubMed  Google Scholar 

  8. H. Grenix, B. Volc-Platzer, and P. Kalhs,Blood,96, 2426–2431 (2000).

    Google Scholar 

  9. D. Hunt, H. Jiang, D. Granville,et al., Immunopharmacology,41, 31–44 (1999).

    Article  PubMed  CAS  Google Scholar 

  10. D. Hunt and J. Levy,Exp. Opin. Investig. Drugs,7, 57–64 (1998).

    Article  CAS  Google Scholar 

  11. H. Jiang, D. J. Granville, J. R. North,et al., Photochem. Photobiol.,76, 224–231 (2002).

    Article  PubMed  CAS  Google Scholar 

  12. M. Korbelik and G. Krosl,|Ibid.Photochem. Photobiol.,60, 160–164 (1994).

    Google Scholar 

  13. M. R. Melamed, T. Lindmo, and M. L. Mendelsonhn,Flow Cytometry and Sorting, New York (1990).

  14. D. Musser and R. Fiel,Photochem. Photobiol.,53, 119–123 (1991).

    PubMed  CAS  Google Scholar 

  15. V. P. Zorin, I. I. Khludeyev, I. S. Mikhalovsky,et al., Proceedings of SPIE,4059, 139–146 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Republican Research-and-Production Center for Child Oncology and Hematology, Minsk

    V. P. Savitskii, V. P. Zorin, M. P. Potapnev & A. Ya. Potapenko

  2. Belarussian State University, Minsk

    V. P. Zorin

  3. Russian State Medical University, Moscow

    A. Ya. Potapenko

Authors
  1. V. P. Savitskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. P. Zorin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. P. Potapnev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Ya. Potapenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. P. Savitskii.

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 8, pp. 180–184, August, 2004

Thisk work was supported by the Belarussian-Russian Foundation for Basic Research (grant NO. B02R-084).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Savitskii, V.P., Zorin, V.P., Potapnev, M.P. et al. Comparative analysis of accumulation of chlorine e6 and hematoporphyrin derivatives in subpopulations of peripheral blood lymphocytes. Bull Exp Biol Med 138, 158–162 (2004). https://doi.org/10.1007/BF02694362

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02694362

Key Words

Search

Navigation