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Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis

  • Genetics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Metabolites ofTrichinella spiralis produced genotoxic and cytotoxic effects on somatic and generative cells of the host organism. They increased the number of single-chain breaks, alkaline-labile sites in nuclear DNA, and count of apoptotic cells in the bone marrow and testes of infected mice. These effects depended on the stage of parasite development in the host organism and became more pronounced with increasing invasion intensity.

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References

  1. B. A. Astaf’ev, L. S. Yarotskii, and M. N. Lebedeva,Experimental Models of Parasitoses in Biology and Medicine [in Russian], Moscow (1989).

  2. Vl. Ya. Bekish,Vestn. Vseros. Gos. Med. Univer.,2, No. 4, 77–84 (2003).

    Google Scholar 

  3. O.-Ya. L. Bekish and Vl. Ya. Bekish, Ibid.Vestn. Vseros. Gos. Med. Univer.,2, No. 4, 67–76 (2003).

    Google Scholar 

  4. O.-Ya. L. Bekish, L. V. Kalinin, and A. V. Stepanov,Dostizheniya Med. Nauki Belarusi, No. 1, 101–102 (1996).

  5. M. Florent, T. Godard, J.-J. Ballet,et al., Cell. Biol. Toxicol.,15, 185–192 (1999).

    Article  PubMed  CAS  Google Scholar 

  6. B. Hellman, H. Vaghef, L. Friis, and C. Edling,Int. Arch. Occup. Environ. Health,69, 185–192 (1997).

    Article  PubMed  CAS  Google Scholar 

  7. K. Konca, A. Lankoff, A. Banasik,et al., Mutat. Res.,534, 15–20 (2003).

    PubMed  CAS  Google Scholar 

  8. C. H. Mak, Y. Y. Chung, and R. C. Ko,Parasitology,120, 527–533 (2000).

    Article  PubMed  CAS  Google Scholar 

  9. C. H. Mak and R. C. Ko,Eur. J. Biochem.,260, 477–481 (1999).

    Article  PubMed  CAS  Google Scholar 

  10. C. H. Mak and R. C. Ko,Parasitology,123, 301–308 (2001).

    Article  PubMed  CAS  Google Scholar 

  11. N. Singh, M. McCoy, R. Tice, and E. Schneider,Exp. Cell Res.,175, 184–191 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. R. Tice, E. Agurell, D. Anderson,et al., Environ. Mol. Mutagen.,35, 206–221 (2000).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Biology and General Genetics, Vitebsk State Medical University, USSR

    Vl.Ya. Bekish

  2. Laboratory for Pharmacology of Mutagenesis, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    A. D. Durnev

Authors
  1. Vl.Ya. Bekish
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  2. A. D. Durnev
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Corresponding author

Correspondence to Vl.Ya. Bekish.

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 320–323, September, 2004

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Bekish, V., Durnev, A.D. Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis. Bull Exp Biol Med 138, 284–287 (2004). https://doi.org/10.1007/BF02694181

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  • DOI: https://doi.org/10.1007/BF02694181

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